Scientific Letters
Vol. 12 No. 1 (2020): Mediterranean Journal of Hematology and Infectious Diseases, Volume 12, 2020
Focusing On A Unique Innate Memory Cell Population Of Natural Killer Cells In The Fight Against COVID-19: Harnessing The Ubiquity Of Cytomegalovirus Exposure
Memory Cell Population Of Natural Killer Cells in COVID-19 and Cytomegalovirus Exposure
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Received: April 19, 2020
Accepted: May 19, 2020
Accepted: May 19, 2020
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References
1. Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, Zhao X, Huang B, Shi W, Lu R et al: A Novel Coronavirus from Patients with Pneumonia in China, 2019. N Engl J Med 2020, 382(8):727-733.
2. Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, Liu L, Shan H, Lei CL, Hui DSC et al: Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med 2020.
3. Chen G, Wu D, Guo W, Cao Y, Huang D, Wang H, Wang T, Zhang X, Chen H, Yu H et al: Clinical and immunologic features in severe and moderate Coronavirus Disease 2019. J Clin Invest 2020.
4. Tian S, Hu N, Lou J, Chen K, Kang X, Xiang Z, Chen H, Wang D, Liu N, Liu D et al: Characteristics of COVID-19 infection in Beijing. J Infect 2020, 80(4):401-406.
5. Zhang C, Wu Z, Li JW, Zhao H, Wang GQ: The cytokine release syndrome (CRS) of severe COVID-19 and Interleukin-6 receptor (IL-6R) antagonist Tocilizumab may be the key to reduce the mortality. Int J Antimicrob Agents 2020:105954.
6. Sun JC, Beilke JN, Lanier LL: Adaptive immune features of natural killer cells. Nature 2009, 457(7229):557-561.
7. Guma M, Budt M, Saez A, Brckalo T, Hengel H, Angulo A, Lopez-Botet M: Expansion of CD94/NKG2C+ NK cells in response to human cytomegalovirus-infected fibroblasts. Blood 2006, 107(9):3624-3631.
8. Foley B, Cooley S, Verneris MR, Pitt M, Curtsinger J, Luo X, Lopez-Verges S, Lanier LL, Weisdorf D, Miller JS: Cytomegalovirus reactivation after allogeneic transplantation promotes a lasting increase in educated NKG2C+ natural killer cells with potent function. Blood 2012, 119(11):2665-2674.
9. Jaiswal SR, Bhakuni P, Bhagawati G, Chakrabarti A, Chakrabarti S: CTLA4Ig-based T-cell costimulation blockade is associated with reduction of adenovirus viremia following post-transplantation cyclophosphamide-based haploidentical transplantation. Bone Marrow Transplant 2019.
10. Jaiswal SR, Bhakuni P, Bhagwati G, Aiyar HM, Chakrabarti A, Chakrabarti S: Alterations In NKG2A and NKG2C Subsets Of Natural Killer Cells following Epstein Barr Virus Reactivation In CTLA4Ig Based Haploidentical Transplantation Is Associated With Increased Chronic Graft-Versus-Host Disease. Transplantation 2019.
11. Jaiswal SR, Bhakuni P, Joy A, Kaushal S, Sudhish D, Aiyer HM, Chakrabarti S: Early Expansion of CD56dimNKG2Alow with Late Surge and Persistence of CD56dimNKG2AnegNKG2Cbright NK Cells Attenuate Cytomegalovirus (CMV) Replication and Recurrence As Well As Leukemia Relapse Following Haploidentical HSCT with T Cell Co-Stimulation Blockade and PTCy. Biology of Blood and Marrow Transplantation 2019, 25(3):S328.
12. Goodier MR, Rodriguez-Galan A, Lusa C, Nielsen CM, Darboe A, Moldoveanu AL, White MJ, Behrens R, Riley EM: Influenza Vaccination Generates Cytokine-Induced Memory-like NK Cells: Impact of Human Cytomegalovirus Infection. J Immunol 2016, 197(1):313-325.
13. Bjorkstrom NK, Lindgren T, Stoltz M, Fauriat C, Braun M, Evander M, Michaelsson J, Malmberg KJ, Klingstrom J, Ahlm C et al: Rapid expansion and long-term persistence of elevated NK cell numbers in humans infected with hantavirus. J Exp Med 2011, 208(1):13-21.
14. Gondois-Rey F, Cheret A, Granjeaud S, Mallet F, Bidaut G, Lecuroux C, Ploquin M, Muller-Trutwin M, Rouzioux C, Avettand-Fenoel V et al: NKG2C(+) memory-like NK cells contribute to the control of HIV viremia during primary infection: Optiprim-ANRS 147. Clin Transl Immunology 2017, 6(7):e150.
15. Geary CD, Sun JC: Memory responses of natural killer cells. Semin Immunol 2017, 31:11-19.
16. Zheng M, Gao Y, Wang G, Song G, Liu S, Sun D, Xu Y, Tian Z: Functional exhaustion of antiviral lymphocytes in COVID-19 patients. Cell Mol Immunol 2020.
17. Vales-Gomez M, Reyburn HT, Erskine RA, Lopez-Botet M, Strominger JL: Kinetics and peptide dependency of the binding of the inhibitory NK receptor CD94/NKG2-A and the activating receptor CD94/NKG2-C to HLA-E. EMBO J 1999, 18(15):4250-4260.
18. Nattermann J, Nischalke HD, Hofmeister V, Kupfer B, Ahlenstiel G, Feldmann G, Rockstroh J, Weiss EH, Sauerbruch T, Spengler U: HIV-1 infection leads to increased HLA-E expression resulting in impaired function of natural killer cells. Antivir Ther 2005, 10(1):95-107.
19. The involvement of natural killer cells in the pathogenesis of severe acute respiratory syndrome. Am J Clin Pathol 2004, 121(4):507-511.
20. Dou Y, Fu B, Sun R, Li W, Hu W, Tian Z, Wei H: Influenza vaccine induces intracellular immune memory of human NK cells. PLoS One 2015, 10(3):e0121258.
21. Wagstaffe HR, Mooney JP, Riley EM, Goodier MR: Vaccinating for natural killer cell effector functions. Clin Transl Immunology 2018, 7(1):e1010.
22. Kleinnijenhuis J, Quintin J, Preijers F, Joosten LA, Jacobs C, Xavier RJ, van der Meer JW, van Crevel R, Netea MG: BCG-induced trained immunity in NK cells: Role for non-specific protection to infection. Clin Immunol 2014, 155(2):213-219.
23. Romee R, Rosario M, Berrien-Elliott MM, Wagner JA, Jewell BA, Schappe T, Leong JW, Abdel-Latif S, Schneider SE, Willey S et al: Cytokine-induced memory-like natural killer cells exhibit enhanced responses against myeloid leukemia. Sci Transl Med 2016, 8(357):357ra123.
24. Chakravarti A, Kashyap B, Matlani M: Cytomegalovirus infection: An Indian perspective. Indian Journal of Medical Microbiology 2009, 27(1):3-11.
1. Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, Zhao X, Huang B, Shi W, Lu R et al: A Novel Coronavirus from Patients with Pneumonia in China, 2019. N Engl J Med 2020, 382(8):727-733.
2. Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, Liu L, Shan H, Lei CL, Hui DSC et al: Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med 2020.
3. Chen G, Wu D, Guo W, Cao Y, Huang D, Wang H, Wang T, Zhang X, Chen H, Yu H et al: Clinical and immunologic features in severe and moderate Coronavirus Disease 2019. J Clin Invest 2020.
4. Tian S, Hu N, Lou J, Chen K, Kang X, Xiang Z, Chen H, Wang D, Liu N, Liu D et al: Characteristics of COVID-19 infection in Beijing. J Infect 2020, 80(4):401-406.
5. Zhang C, Wu Z, Li JW, Zhao H, Wang GQ: The cytokine release syndrome (CRS) of severe COVID-19 and Interleukin-6 receptor (IL-6R) antagonist Tocilizumab may be the key to reduce the mortality. Int J Antimicrob Agents 2020:105954.
6. Sun JC, Beilke JN, Lanier LL: Adaptive immune features of natural killer cells. Nature 2009, 457(7229):557-561.
7. Guma M, Budt M, Saez A, Brckalo T, Hengel H, Angulo A, Lopez-Botet M: Expansion of CD94/NKG2C+ NK cells in response to human cytomegalovirus-infected fibroblasts. Blood 2006, 107(9):3624-3631.
8. Foley B, Cooley S, Verneris MR, Pitt M, Curtsinger J, Luo X, Lopez-Verges S, Lanier LL, Weisdorf D, Miller JS: Cytomegalovirus reactivation after allogeneic transplantation promotes a lasting increase in educated NKG2C+ natural killer cells with potent function. Blood 2012, 119(11):2665-2674.
9. Jaiswal SR, Bhakuni P, Bhagawati G, Chakrabarti A, Chakrabarti S: CTLA4Ig-based T-cell costimulation blockade is associated with reduction of adenovirus viremia following post-transplantation cyclophosphamide-based haploidentical transplantation. Bone Marrow Transplant 2019.
10. Jaiswal SR, Bhakuni P, Bhagwati G, Aiyar HM, Chakrabarti A, Chakrabarti S: Alterations In NKG2A and NKG2C Subsets Of Natural Killer Cells following Epstein Barr Virus Reactivation In CTLA4Ig Based Haploidentical Transplantation Is Associated With Increased Chronic Graft-Versus-Host Disease. Transplantation 2019.
11. Jaiswal SR, Bhakuni P, Joy A, Kaushal S, Sudhish D, Aiyer HM, Chakrabarti S: Early Expansion of CD56dimNKG2Alow with Late Surge and Persistence of CD56dimNKG2AnegNKG2Cbright NK Cells Attenuate Cytomegalovirus (CMV) Replication and Recurrence As Well As Leukemia Relapse Following Haploidentical HSCT with T Cell Co-Stimulation Blockade and PTCy. Biology of Blood and Marrow Transplantation 2019, 25(3):S328.
12. Goodier MR, Rodriguez-Galan A, Lusa C, Nielsen CM, Darboe A, Moldoveanu AL, White MJ, Behrens R, Riley EM: Influenza Vaccination Generates Cytokine-Induced Memory-like NK Cells: Impact of Human Cytomegalovirus Infection. J Immunol 2016, 197(1):313-325.
13. Bjorkstrom NK, Lindgren T, Stoltz M, Fauriat C, Braun M, Evander M, Michaelsson J, Malmberg KJ, Klingstrom J, Ahlm C et al: Rapid expansion and long-term persistence of elevated NK cell numbers in humans infected with hantavirus. J Exp Med 2011, 208(1):13-21.
14. Gondois-Rey F, Cheret A, Granjeaud S, Mallet F, Bidaut G, Lecuroux C, Ploquin M, Muller-Trutwin M, Rouzioux C, Avettand-Fenoel V et al: NKG2C(+) memory-like NK cells contribute to the control of HIV viremia during primary infection: Optiprim-ANRS 147. Clin Transl Immunology 2017, 6(7):e150.
15. Geary CD, Sun JC: Memory responses of natural killer cells. Semin Immunol 2017, 31:11-19.
16. Zheng M, Gao Y, Wang G, Song G, Liu S, Sun D, Xu Y, Tian Z: Functional exhaustion of antiviral lymphocytes in COVID-19 patients. Cell Mol Immunol 2020.
17. Vales-Gomez M, Reyburn HT, Erskine RA, Lopez-Botet M, Strominger JL: Kinetics and peptide dependency of the binding of the inhibitory NK receptor CD94/NKG2-A and the activating receptor CD94/NKG2-C to HLA-E. EMBO J 1999, 18(15):4250-4260.
18. Nattermann J, Nischalke HD, Hofmeister V, Kupfer B, Ahlenstiel G, Feldmann G, Rockstroh J, Weiss EH, Sauerbruch T, Spengler U: HIV-1 infection leads to increased HLA-E expression resulting in impaired function of natural killer cells. Antivir Ther 2005, 10(1):95-107.
19. The involvement of natural killer cells in the pathogenesis of severe acute respiratory syndrome. Am J Clin Pathol 2004, 121(4):507-511.
20. Dou Y, Fu B, Sun R, Li W, Hu W, Tian Z, Wei H: Influenza vaccine induces intracellular immune memory of human NK cells. PLoS One 2015, 10(3):e0121258.
21. Wagstaffe HR, Mooney JP, Riley EM, Goodier MR: Vaccinating for natural killer cell effector functions. Clin Transl Immunology 2018, 7(1):e1010.
22. Kleinnijenhuis J, Quintin J, Preijers F, Joosten LA, Jacobs C, Xavier RJ, van der Meer JW, van Crevel R, Netea MG: BCG-induced trained immunity in NK cells: Role for non-specific protection to infection. Clin Immunol 2014, 155(2):213-219.
23. Romee R, Rosario M, Berrien-Elliott MM, Wagner JA, Jewell BA, Schappe T, Leong JW, Abdel-Latif S, Schneider SE, Willey S et al: Cytokine-induced memory-like natural killer cells exhibit enhanced responses against myeloid leukemia. Sci Transl Med 2016, 8(357):357ra123.
24. Chakravarti A, Kashyap B, Matlani M: Cytomegalovirus infection: An Indian perspective. Indian Journal of Medical Microbiology 2009, 27(1):3-11.
How to Cite
“Focusing On A Unique Innate Memory Cell Population Of Natural Killer Cells In The Fight Against COVID-19: Harnessing The Ubiquity Of Cytomegalovirus Exposure: Memory Cell Population Of Natural Killer Cells in COVID-19 and Cytomegalovirus Exposure” (2020) Mediterranean Journal of Hematology and Infectious Diseases, 12(1), p. e2020047. doi:10.4084/mjhid.2020.047.
