COVID-19 post hematopoietic cell transplant, a report of 11 cases from a single center.
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Keywords
Coronavirus, COVID-19, SARS-CoV-2, hematopoietic cell transplant, bone, marrow transplant, stem cell transplant, multiple myeloma, acute lymphoblastic leukemia, lymphoma
Abstract
In late 2019 the coronavirus disease-2019 (COVID-19) pandemic caused by SARS Coronavirus 2 (SARS-CoV-2) started in Wuhan, China. Cancer patients are immunosuppressed from their disease and the therapy they receive. Hematopoietic cell transplant (HCT) recipients are a subgroup of patients that are severely immunocompromised and may be at an even higher risk of a complicated course during this infection. We herein report the outcomes and course of 11 sequential cases of HCT recipients infected by SARS-CoV-2 treated in our center. The patients age ranged from 17 to 60 years, the duration from transplant to infection ranged from day +5 to 192 months, 6 patients were post allo-HCT, 4 post auto-HCT and one had both allo and auto-HCT. The presenting symptoms were not different from other viral illnesses. The majority had mild COVID-19 stage, while 3 had moderate stage on presentation. None of the patients required oxygen supplementation nor mechanical ventilation.
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