Case Reports
Vol. 13 No. 1 (2021): Mediterranean Journal of Hematology and Infectious Diseases, Volume 13, 2021
Aberrant acquisition of T-cell associated markers in plasma cell neoplasms: An aggressive disease with extramedullary involvement and very short survival
Aberrant T markers on malignant plasma cells
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Received: April 1, 2021
Accepted: May 26, 2021
Accepted: May 26, 2021
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Background:
Plasma cell neoplasms can show aberrant expression of a different lineage-related antigens, however, co-expression of T-cell associated markers on malignant plasma cells is extremely rare.
Material and methods: This is a report of clinicopathologic characteristics of three myeloma patients with emergent plasmablastic morphology and aberrant acquisition of T‐cell associated markers. An extensive literature search for similar cases was conducted and the relevant pathologic, clinical and prognostic characteristics were summarized.
Results: A total of 22 cases of plasma cell neoplasm, showed aberrant co-expression of T-cell markers. We found an evident association between aberrant expression of T-cell markers on malignant plasma cells and extramedullary involvement, aggressive morphologic features, high proliferative index ki67 >90%, aggressive clinical course, adverse outcome with short survival.
Conclusion:
Due to rarity of this aberrant phenotype and scarcity of the published data, the precise causative mechanism and its clinical implications have not yet been elucidated.
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Citations
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How to Cite
“ Aberrant acquisition of T-cell associated markers in plasma cell neoplasms: An aggressive disease with extramedullary involvement and very short survival: Aberrant T markers on malignant plasma cells” (2021) Mediterranean Journal of Hematology and Infectious Diseases, 13(1), p. e2021043. doi:10.4084/MJHID.2021.043.
Copyright (c) 2021 Dina Sameh Soliman, Hesham Elsabah, Ibrahim Ganwo, Aliaa Amer, Ruba Y Taha, Lajos Szabados , Mouhammad Sharaf Eldean, Ahmad Al-Sabbagh, Feryal Ibrahim
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
