Could the 3′UTR+101G>C Mutation Detected in Two Sibling Cases Be a Mutation Affecting the Clinical Presentation in Thalassemia Patients?

Main Article Content

Unal Atas
Volkan Karakus
Erdal Kurtoglu


Transfusion-dependent β-thalassemia, β-thalassemia mutations, 3′UTR+101G>C mutation


Due to letter to aditor, there is no abstract.


Download data is not yet available.

Abstract 192
PDF Downloads 396
HTML Downloads 15


1. Thein PL. The molecular basis of beta-thalassemia. Cold Spring Harb Perspect Med 2013;3:a011700. Doi: 10.1101/cshperspect.a011700
2. Modell B, Darlison M (2008) Global epidemiology of hemoglobin disorders and derived service indicators. Bull World Health Organ 86: 480–487. Doi: 10.2471/blt.06.036673
3. Kountouris P, Lederer CW, Fanis P, Feleki X, Old J, Kleanthous M. IthaGenes: an interactive database for hemoglobin variations and epidemiology. PLoS One 2014;9:e103020. Doi: 10.1371/journal.pone.0103020
4. Guzelgul F, Seydel GS, Aksoy K. β-Globin Gene Mutations in Pediatric Patients with β-Thalassemia in the Region of Çukurova, Turkey. Hemoglobin. 2020 Jul;44(4):249-253. Doi: 10.1080/03630269.2020.1792489.
5. Molecular Understanding of Severe Cases of β-Thalassemia in the Nablus Region, West Bank, Palestine. Samha L, Sirdah MM, Reading NS, Karmi B, Agarwal AM. Hemoglobin. 2020 Mar;44(2):128-130. Doi: 10.1080/03630269.2020.1763398.
6. Updated Molecular Spectrum of β-Thalassemia Mutations in Duhok Province, Northern Iraq: Ethnic Variation and the Impact of Immigration. Atroshi SD, Al-Allawi NAS, Eissa AA. Hemoglobin. 2021 Jul;45(4):239-244. Doi: 10.1080/03630269.2021.1984250.
7. The Spectrum of β-Thalassemia Mutations in the Population Migration in Lebanon: A 6-Year Retrospective Study. Farra C, Abdouni L, Souaid M, Awwad J, Yazbeck N, Abboud M. Hemoglobin. 2021 Nov;45(6):365-370. Doi: 10.1080/03630269.2021.1920975.
8. Nazı Başak A. The molecular pathology of β-thalassemia in Turkey: the Boğaziçi University experience. Hemoglobin. 2007;31(2):233–241. Doi: 10.1080/03630260701296735
9. Tadmouri GO, Başak AN. β Thalassemia in Turkey: a review of the clinical, epidemiological, molecular, and evolutionary aspects. Hemoglobin. 2001;25(2):227–239. Doi: 10.1081/hem-100104031