Original Articles
Vol. 16 No. 1 (2024): Review Articles, Original Article, Scientific Letter, Case Reports Letter to the Editor
https://doi.org/10.4084/MJHID.2024.072

ANTIBIOTIC LOCK THERAPY FOR PORT CATHETER-RELATED INFECTIONS OF CHILDREN WITH ACUTE LEUKEMIA

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Received: June 24, 2024
Accepted: August 16, 2024
Published: August 31, 2024
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Acute leukemia,, central venous catheter, Antibiotic Lock therapy, Infection

Authors

Burçin Kurtipek
burcindogan86@gmail.com
a:1:{s:5:"en_US";s:31:"Ankara Bilkent şehir hastanesi";}, Türkiye.
Ayça Koca Yozgat
Saliha Kanık Yüksek
Dilek Kaçar
Turan Bayhan
Dilek Gürlek Gökçebay
Aslınur Özkaya Parlak
Neşe Yaralı

Background: Port catheters facilitate the administration of chemotherapy, antibiotics, blood products, fluid and parenteral nutritional support to pediatric patients with hematological malignancies. However, as its use has become widespread, local, and systemic catheter-related infections have emerged as important causes of morbidity and mortality. In our study, we aimed to evaluate the success of antibiotic lock therapy in port catheter- related infections of pediatric patients followed up with acute leukemia.

Methods: Port catheter cultures taken from a total of 182 pediatric patients with acute lymphoblastic/myeloblastic leukemia who were followed up at Ankara City Hospital Pediatric Hematology Clinic between August 2019 and August 2023 were evaluated retrospectively. Results: Bacterial growth was identified in 739 port catheter culture specimens of 182 patients. Closure or removal of the port was required in 91, and removal of the port catheters in 49 patients due to port catheter-related infections. Antibiotic lock therapy was started in 56 patients with bacterial growth in the port catheter. With antibiotic lock therapy, port catheter-related infections of 42 patients were eradicated, and their catheters began to be used again. As a result, the port catheter-related infections of 42 of 56 (75%) patients whose ports were closed and also received systemic antibiotherapy were eradicated, and no recurrence of infection was observed.

Conclusion: Adding antibiotic lock therapy to systemic antibiotics in pediatric patients may be beneficial in terms of catheter salvage.

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How to Cite



“ANTIBIOTIC LOCK THERAPY FOR PORT CATHETER-RELATED INFECTIONS OF CHILDREN WITH ACUTE LEUKEMIA” (2024) Mediterranean Journal of Hematology and Infectious Diseases, 16(1), p. e2024072. doi:10.4084/MJHID.2024.072.
Copyright (c) 2024 burçin kurtipek; Ayça Koca Yozgat, saliha kanık yüksek, Dilek Kaçar, Turan Bayhan, Dilek Gürlek Gökçebay, Aslınur Özkaya Parlak, Neşe Yaralı Creative Commons License

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