Review Articles
Vol. 17 No. 1 (2025): Review Articles, Original Article, Scientific Letter, Case Reports Letter to the Editor
TOXICITIES ASSOCIATED WITH CAR-T CELL THERAPIES
CAR-T Cell Toxicity
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Received: March 5, 2025
Accepted: March 5, 2025
Accepted: March 5, 2025
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Chimeric antigen receptor (CAR) T-cells therapy has improved the outcomes of patients with relapsed/refractory B-cell lymphomas, B-cell acute lymphoblastic leukemia and multiple myeloma. However, CAR-T cell therapy is also associated with distinct toxicities that contribute to morbidity and mortality. A large number of studies now define the different toxicities associated with CAR-T cell therapy and have, in part, clarified their mechanisms. In particular, cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS) are the two main acute toxicity events that occur after CAR-T cell infusion. Other CAR-T-related toxicities occur later after CAR-T cell infusion and include B-cell aplasia, hypogammaglobulinemia, infections and cytopenia. Infections represent the main cause of non-relapse death observed in patients undergoing CAR-T cell therapy. Second primary malignancies are rare and are mainly represented by myeloid malignancies.
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How to Cite
“TOXICITIES ASSOCIATED WITH CAR-T CELL THERAPIES: CAR-T Cell Toxicity” (2025) Mediterranean Journal of Hematology and Infectious Diseases, 17(1), p. e2025039. doi:10.4084/MJHID.2025.039.
Copyright (c) 2025 Ugo Testa, Dr. Germana Castelli, Dr. Elvira Pelosi, Dr. Galli, Prof. Patrizia Chiusolo
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
