Bone marrow involvement in a patient with alpha heavy chain disease:Response to tetracycline treatment

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Zahit Bolaman
Irfan Yavasoglu
Gokhan Sargin *
Gurhan Kadikoylu
Firuzan Kacar Doger
(*) Corresponding Author:
Gokhan Sargin | gokhan_sargin@hotmail.com

Abstract

A 28-year-old man admitted with abdominal pain, weight loss and diarrhea. Barium x-ray studies showed segmentation, dilatation of bowel loops, mucosal folds thickening and delayed intestinal transit. Biopsy specimens histologically revelaed villous atrophy and plasmacytic infiltration limited to mucosa and submucosa. Computed tomography showed multiple lymphadenopathy in the abdomen. Serum protein electropheresis and immunoelectropheresis indicated elevated IgA concentration. Bone marrow aspiration and biopsy revealed presence of lymphoplasmacytic infiltration. Immunohistochemical analysis of the intestine, lymph node showed positivity for CD45, CD-79, CD-20.  After tetracycline treatment the patient’s symptoms, abdominal lymphadenopathy and bone marrow infiltration disappeared and IgA concentration was normalized.


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Author Biographies

Zahit Bolaman, Adnan Menderes University Medical Faculty, Division of Hematology

Adnan Menderes University Medical Faculty, Division of Hematology

Irfan Yavasoglu, Adnan Menderes University Medical Faculty, Division of Hematology

Adnan Menderes University Medical Faculty, Division of Hematology

Gokhan Sargin, Adnan Menderes University Medical Faculty, Division of Hematology

Adnan Menderes University Medical Faculty, Division of Hematology

Gurhan Kadikoylu, Adnan Menderes University Medical Faculty, Division of Hematology

Adnan Menderes University Medical Faculty, Division of Hematology

Firuzan Kacar Doger, Adnan Menderes University Medical Faculty, Division of Pathology

Adnan Menderes University Medical Faculty, Division of Pathology