Case Reports
Vol. 10 (2018): Review Articles, Original Articles, Scientific Letters, Case Reports
Parvovirus B19-triggered acute hemolytic anemia and thrombocytopenia in a child with Evans syndrome
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Received: November 19, 2017
Accepted: January 24, 2018
Accepted: January 24, 2018
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Pediatric Hematology
Authors
Background: Human parvovirus B19 (HPV-B19) is the etiologic agent of erythema infectiosum, of transient aplastic crises in individuals with underlying chronic hemolytic disorders, and of chronic pure red cell aplasia in immunocompromised individuals.
Case report. We describe a 14-year-old girl with long-standing Evans syndrome, who presented with severe anemia, reticulocytopenia and thromocytopenia. A bone marrow aspirate revealed severe erythroid hypoplasia along with presence of giant pronormoblasts, while serological studies and real-time PCR of whole blood were positive for acute parvovirus B19 infection. The patient was initially managed with corticosteroids, but both cytopenias resolved only after administration of intravenous gamma globulin 0.8g/kg.
Conclusion: Acute parvovirus B19 infection should be suspected in patients with immunologic diseases, who present with reticulocytopenic hemolytic anemia and thrombocytopenia. In this setting, intravenous gamma globulin is effective for both cytopenias.
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Citations
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Case ReportHow to Cite
“Parvovirus B19-triggered acute hemolytic anemia and thrombocytopenia in a child with Evans syndrome” (2018) Mediterranean Journal of Hematology and Infectious Diseases, 10(1), p. e2018018. doi:10.4084/mjhid.2018.018.
