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• JUSTIFICATION OF UNIVERSAL IRON SUPPLEMENTATION FOR INFANTS 6-12 MONTHS IN REGIONS WITH A HIGH PREVALENCE OF THALASSEMIA Iron Supplementation for Infants 6-12 months in Regions with a High Prevalence of Thalassemia

  Phakatip Sinlapamongkolkul, Pacharapan Surapolchai, Vip Viprakasit

  e2023056

  2023-08-29

  https://doi.org/10.4084/MJHID.2023.056

  2298

  PDF: 621

  Suppl. Files: 286

  HTML: 178

• THE EFFECT OF ALPHA THALASSEMIA, HBF and HBC ON HAEMATOLOGICAL PARAMETERS OF SICKLE CELL DISEASE PATIENTS IN IBADAN, NIGERIA. ALPHA THALASSEMIA, HBF and HBC ON HAEMATOLOGICAL PARAMETERS OF SICKLE CELL DISEASE PATIENTS

  FASOLA ATINUKE

  e2022001

  2022-01-01

  https://doi.org/10.4084/MJHID.2022.001

  2720

  PDF: 993

  HTML: 77

• THE COURSE OF HEPATITIS C INFECTION AND RESPONSE TO ANTI-VIRAL THERAPY IN PATIENTS WITH THALASSEMIA MAJOR AND HEPATITIS C INFECTION: A LONGITUDINAL, PROSPECTIVE STUDY.

  Sanaa Kamal, Sara Abdelhakam, Dr., Dahlia Ghoraba, Mohamad Amer Mohsen, Ahmed Abdelsalam, Huda Hassan, Leila Nabeigh

  e2019060

  2019-10-30

  https://doi.org/10.4084/mjhid.2019.060

  1399

  PDF: 1051

  HTML: 211

• SUBTYPE DISTRIBUTION AND MUTATION SPECTRUM THALASSEMIA IN CHILDREN UNDER 10 YEARS IN NORTHERN VIETNAM

  Ngoc Dung Nguyen, Ha Thanh Nguyen, Thi Chi Nguyen, Thi Nguyet Anh Phi, Thi Thu Ha Nguyen, Thi Thu Huyen Le, Phuong Linh Hoang, Duc Binh Vu

  e2026002

  2026-01-01

  https://doi.org/10.4084/MJHID.2026.002

  971

  PDF: 661

  Html: 188

• PREVALENCE OF THALASSEMIA IN THE VIETNAMESE POPULATION AND BUILDING A CLINICAL DECISION SUPPORT SYSTEM FOR PRENATAL SCREENING FOR THALASSEMIA

  Danh Cuong Tran, Anh Linh Dang, Thi Ngoc Lan Hoang, Chi Thanh Nguyen, Thi Ngoc Mai Dinh, Van Anh Tran, Thi Kim Phuong Doan, Thi Trang Nguyen

  e2023026

  2023-04-28

  https://doi.org/10.4084/MJHID.2023.026

  4765

  HTML: 326

  PDF: 1263

• ?-THALASSEMIA DISTRIBUTION IN THE OLD WORLD: A HISTORICAL STANDPOINT OF AN ANCIENT DISEASE

  Vincenzo De Sanctis

  e2017018

  2017-02-20

  https://doi.org/10.4084/mjhid.2017.018

  11183

  PDF: 4378

  HTML: 4371

• SPECTRUM OF BETA GLOBIN GENE MUTATIONS IN EGYPTIAN CHILDREN WITH ?- THALASSEMIA

  MR El-Shanshory, Adel Abd Elhaleim Hagag

  e2014071

  2014-08-28

  https://doi.org/10.4084/mjhid.2014.071

  2091

  PDF: 1048

  HTML: 4247

• STUDY OF SERUM HAPTOGLOBIN LEVEL AND ITS RELATION TO ERYTHROPOIETIC ACTIVITY IN BETA THALASSEMIA CHILDREN .

  Seham Ragab, Manal A. Safan, Eman A. Badr

  e2015019

  2015-02-12

  https://doi.org/10.4084/mjhid.2015.019

  2225

  PDF: 1177

  HTML: 2595

  Study of serum haptoglobin level in thalassemia: 352

  Figures: 185

• PREVENTION OF ? THALASSEMIA IN NORTHERN ISRAEL - A COST-BENEFIT ANALYSIS.

  Ariel Koren, Lora Profeta, Luci Zalman, Haya Palmor, Carina Levin, Ronit Bril Zamir, Stavit Shalev, Orna Blondheim

  e2014012

  2014-02-17

  https://doi.org/10.4084/mjhid.2014.012

  2584

  PDF: 1221

  HTML: 11809

• PREVALENCE OF ALPHA THALASSEMIA IN MICROCYTIC ANEMIA: A TERTIARY CARE EXPERIENCE FROM NORTH INDIA

  Monica Sharma, Sanjay Pandey, Ravi Ranjan, Tulika Seth, Renu Saxena

  e2015004

  2015-01-01

  https://doi.org/10.4084/mjhid.2015.004

  2453

  PDF: 1240

  HTML: 4737

  table: 214

  fig 1: 224

  fig 2: 180

• EFFICACY AND SAFETY OF THALIDOMIDE IN PATIENTS WITH TRANSFUSION-DEPENDENT β-THALASSEMIA: A SYSTEMATIC REVIEW, META-ANALYSIS AND GRADE EVALUATION

  Jialian Li, Ping Ji, Qinyue Zhong, Lin Dong, Hai Yi, Baiyu Chen, Xu Zhang, Tingting Duan

  e2026033

  2026-04-30

  https://doi.org/10.4084/MJHID.2026.033

  250

  PDF: 253

  Suppl. Files: 42

  HTML: 20

• PREDISPOSING FACTORS TO INFECTIONS IN THALASSEMIA SYNDROME PATIENTS

  Eman M Mansory, Lina M. Abdulrahman, Balsam Osman, Sawsan M. Sawsan, Assil F. Ruckn, Marwa Aljedaani, Nemmat Hassan, Ahmed S. Barefah, Hatem M. Alahwal, Yassir Daghistani, Salem M. Bahashwan, Abdullah T. Almohammadi, Osman O. Radhwi

  e2025055

  2025-08-31

  https://doi.org/10.4084/MJHID.2025.055

  1767

  PDF: 1476

  HTML: 359

• PREVALENCE OF THALASSEMIA AMONG NEWBORNS: A RE-VISITED AFTER 20 YEARS OF A PREVENTION AND CONTROL PROGRAM IN NORTHEAST THAILAND.

  Goonnapa Fucharoen

  e2018054

  2018-09-01

  https://doi.org/10.4084/mjhid.2018.054

  1814

  PDF: 1099

  HTML: 222

• DETECTION OF ? THALASSEMIA CARRIERS BY RED CELL PARAMETERS OBTAINED FROM AUTOMATIC COUNTERS USING MATHEMATICAL FORMULAS

  Idit Lachover Roth, Boaz Lachover, Guy Koren, Carina Levin, Luci Zalman, Ariel Koren

  e2018008

  2018-01-01

  https://doi.org/10.4084/mjhid.2018.008

  4876

  PDF: 1735

  HTML: 1108

• HEMATOPOIETIC STEM CELL TRANSPLANTATION IN THALASSEMIA AND SICKLE CELL DISEASE: EXPERIENCE OF MEDITERRANEAN INSTITUTE OF HEMATOLOGY IN A MULTI-ETHNIC POPULATION.

  Marco Marziali, Antonella Isgrò, Javid Gaziev, Guido Lucarelli

  e2009027

  2009-12-26

  1710

  PDF: 730

  HTML: 2922

• EFFECT OF CIS ACTING POTENTIAL REGULATORS IN THE ß GLOBIN GENE CLUSTER ON THE PRODUCTION OF HBF IN THALASSEMIA PATIENTS

  Anita Nadkarni

  e2013012

  2013-02-16

  https://doi.org/10.4084/mjhid.2013.012

  1143

  PDF: 605

  HTML: 3341

• INFECTIONS IN THALASSEMIA AND HEMOGLOBINOPATHIES

  Bianca Maria Ricerca, Arturo Di Girolamo, Deborah Rund

  e2009028

  2009-12-28

  1093

  PDF: 619

  HTML: 4414

• WHAT UNRELATED HEMATOPOIETIC STEM CELL TRANSPLANTATION IN THALASSEMIA TAUGHT US ABOUT TRANSPLANT IMMUNOGENETICS.

  Giorgio La Nasa, Adriana Vacca, Roberto Littera, Eugenia Piras, Sandro Orru, Marianna Greco, Carlo Carcassi, Giovanni Caocci

  e2016048

  2016-10-20

  https://doi.org/10.4084/mjhid.2016.048

  3178

  PDF: 1151

  HTML: 1501

  Untitled: 182

  Untitled: 175

  Untitled: 176

• RECENT INSIGHTS INTO THE POPULATION GENETICS AND DYNAMICS OF THE INHERITED DISORDERS OF HEMOGLOBIN

  David J Weatherall

  e2009022

  2009-12-20

  1058

  PDF: 452

  HTML: 584

• CONCISE REVIEW ON THE FREQUENCY, MAJOR RISK FACTORS AND SURVEILLANCE OF HEPATOCELLULAR CARCINOMA (HCC) IN ?-THALASSEMIAS: PAST, PRESENT AND FUTURE PERSPECTIVES Thalassaemia transfusion dependent, Hepatitis C, hepatocarcinoma.

  Vincenzo De Sanctis

  e2020006

  2020-01-01

  https://doi.org/10.4084/mjhid.2020.006

  4306

  PDF: 1534

  HTML: 460

• GENETIC HETEROGENEITY OF BETA GLOBIN MUTATIONS AMONG ASIAN-INDIANS AND IMPORTANCE IN GENETIC COUNSELLING AND DIAGNOSIS

  Ravindra Kumar, Kritanjali Singh, Inusha Panigrahi, Sarita Agarwal

  e2013003

  2013-01-01

  https://doi.org/10.4084/mjhid.2013.003

  1778

  PDF: 1296

  HTML: 11519

  Figure1: 179

  Figure 2: 181

• EVALUATION OF GLUTATHIONE-S-TRANSFERASE P1 POLYMORPHISM AND ITS RELATION TO BONE MINERAL DENSITY IN EGYPTIAN CHILDREN AND ADOLESCENTS WITH BETA- THALASSEMIA MAJOR

  Seham Ragab

  e2016004

  2016-01-01

  https://doi.org/10.4084/mjhid.2016.004

  3936

  PDF: 864

  HTML: 2438

  Figures: 172

• CARDIAC FUNCTION AND IRON CHELATION IN THALASSEMIA MAJOR AND INTERMEDIA: A REVIEW OF THE UNDERLYING PATHOPHYSIOLOGY AND APPROACH TO CHELATION MANAGEMENT

  Athanasios Aessopos, Vasilios Berdoukas

  e2009002

  2009-07-18

  1603

  PDF: 488

  HTML: 1447

• Measurement of erythrocyte lifespan using a CO breath test in patients with thalassemia and the impact of treatment erythrocyte lifespan in patients with thalassemia

  xiaolin yin, Jingting Luo

  e2023050

  2023-08-29

  https://doi.org/10.4084/MJHID.2023.050

  776

  PDF: 556

  HTML: 174

• COMPREHENSIVE REVIEW OF GENETIC AND EPIGENETICS REGULATION OF FETAL HEMOGLOBIN IN β-HEMOGLOBINOPATHIES: FROM MOLECULAR MECHANISMS TO CLINICAL APPLICATIONS HbF Genetics in Anemia

  Yousef Saeed Mohammad Abu Za’ror, Joseph Bagi Suleiman, Fatima Azzahra Delmani, Jehad Farouq Alhmoud, Amer Mohammad Ayasreh, Sarah Ihsan Al-wendawi, Maryam Azlan

  e2026046

  2026-04-30

  https://doi.org/10.4084/MJHID.2026.046

  506

  PDF: 378

  HTML: 46

• HEALTH-RELATED QUALITY OF LIFE IN THAI CHILDREN WITH THALASSEMIA AS EVALUATED BY PEDSQL AND EQ-5D-Y: A SINGLE CENTER EXPERIENCE

  Pacharapan Surapolchai, Phakatip Sinlapamongkolkul

  e2020036

  2020-06-28

  https://doi.org/10.4084/mjhid.2020.036

  1546

  PDF: 1140

  HTML: 320

• Invasive Pulmonary Aspergillosis in a Sickle Cell Patient Transplant Recipient: A Successful Treatment

  Katia Paciaroni, Gioia De Angelis, Cristiano Gallucci, Cecilia Alfieri, Michela Ribersani, Andrea Roveda, Antonella Isgrò, Marco Marziali, Ivan Pietro Aloi, Alessandro Inserra, Javid Gaziev, Pietro Sodani, Guido Lucarelli

  e2015006

  2015-08-01

  https://doi.org/10.4084/mjhid.2015.006

  1952

  PDF: 1115

  HTML: 1900

  Lung computed tomography CT scan image: 208

• THE HISTORY OF DEFERIPRONE (L1) AND THE COMPLETE TREATMENT OF IRON OVERLOAD IN THALASSAEMIA The history and roles of deferiprone

  George J Kontoghiorghes, Marios Kleanthous, Christina N. Kontoghiorghe

  e2020011

  2020-01-01

  https://doi.org/10.4084/mjhid.2020.011

  2437

  PDF: 1601

  HTML: 651

• A MULTICENTER ICET-A SURVEY ON ADHERENCE TO ANNUAL ORAL GLUCOSE TOLERANCE TEST (OGTT) SCREENING IN TRANSFUSION-DEPENDENT THALASSEMIA (TDT) PATIENTS - THE EXPERT CLINICIANS’ OPINION ON FACTORS INFLUENCING THE ADHERENCE AND ON ALTERNATIVE STRATEGIES FOR ADHERENCE OPTIMIZATION Survey on adherence to annual OGTT in thalassemia

  Vincenzo De Sanctis

  e2025008

  2024-12-31

  https://doi.org/10.4084/MJHID.2025.008

  2939

  PDF: 1354

  HTML: 161

• THE ICET-A SURVEY ON CURRENT CRITERIA USED BY CLINICIANS FOR THE ASSESSMENT OF CENTRAL ADRENAL INSUFFICIENCY IN THALASSEMIA: ANALYSIS OF RESULTS AND RECOMMENDATIONS

  Vincenzo De Sanctis

  e2016034

  2016-07-01

  https://doi.org/10.4084/mjhid.2016.034

  3665

  PDF: 916

  HTML: 1735

• ASSOCİATİON BETWEEN IRON OVERLOAD AND GLUCOSE METABOLİSM İN CHİLDREN AND YOUTH WİTH TRANSFUSİON-DEPENDENT BETA THALASSEMİA: THE ROLE OF CHELATİON THERAPY

  Deniz Guven, Dr. İncefidan, Dr. Kazanci, Dr. Ozlem Kara

  2026-02-28

  https://doi.org/10.4084/MJHID.2026.017

  675

  PDF: 568

  HTML: 73

• THE PERFORMANCE OF HOMA 2 COMPARED TO DYNAMIC MARKERS OF INSULIN SECRETION AND SENSITIVITY/RESISTANCE FOR PREDICTING DYSGLYCEMIA IN TRANSFUSION-DEPENDENT Β-THALASSEMIA: THE EXPERIENCE OF A SINGLE CENTRE HOMA 2 and DYNAMIC MARKERS OF INSULIN SECRETION FOR PREDICTING DYSGLYCEMIA  in TDT

  Vincenzo De Sanctis, Shahina Daar, Ploutarchos Tzoulis, Ashraf Soliman, Ihab Elhakim , Mohammad Faranoush, Christos Kattamis

  e2026055

  2026-06-30

  https://doi.org/10.4084/MJHID.2026.056

  99

  PDF: 78

  HTML: 14

• A SEROPREVALENCE OF HBV, HCV AND HIV-1 AND CORRELATION WITH MOLECULAR MARKERS AMONG MULTI-TRANSFUSED THALASSEMIA PATIENTS IN WESTERN INDIA Incidence of serology & molecular of HIV, HBV and HCV in thalassemia patients

  Kanchan Mishra, Avani Shah, Krima Patel, Kanjaksha Ghosh, Sumit Bharadva

  e2020038

  2020-06-28

  https://doi.org/10.4084/mjhid.2020.038

  1379

  PDF: 769

  HTML: 524

• CLINICAL AND BIOCHEMICAL DATA OF ADULT THALASSEMIA MAJOR PATIENTS (TM) WITH MULTIPLE ENDOCRINE COMPLICATIONS (MEC) VERSUS TM PATIENTS WITH NORMAL ENDOCRINE FUNCTIONS: A RETROSPECTIVE LONG-TERM STUDY (40 YEARS) IN A TERTIARY CARE CENTER IN ITALY

  Vincenzo De Sanctis, Heba Elsedfy

  e2016022

  2016-04-12

  https://doi.org/10.4084/mjhid.2016.022

  3806

  PDF: 1036

  HTML: 3497

• IRON METABOLISM IN THALASSEMIA AND SICKLE CELL DISEASE

  Raffaella Mariani, Paola Trombini, Matteo Pozzi, Alberto Piperno

  e2009006

  2009-10-27

  1651

  PDF: 653

  HTML: 43924

• THALASSAEMIA INTERMEDIA : AN UPDATE

  Ali Taher, Khaled M. Musallam, Maria Domenica Cappellini

  e2009004

  2009-08-17

  1078

  PDF: 443

  HTML: 9451

• QUANTITATIVE ANALYSIS OF LIVER IRON DEPOSITION BASED ON DUAL-ENERGY CT IN THALASSEMIA PATIENTS

  Fengming Xu, Cheng Tang, Yiling Huang, Linlin Liang, Fuling Huang, Gaohui Yang, Peng Peng

  e2023020

  2023-02-28

  https://doi.org/10.4084/MJHID.2023.020

  974

  PDF: 916

  HTML: 383

• THERAPEUTIC VALUE OF COMBINED THERAPY WITH DEFERASIROX AND SILYMARIN ON IRON OVERLOAD IN CHILDREN WITH BETA THALASSEMIA

  adel abd elhaleim hagag

  e2013065

  2013-11-04

  https://doi.org/10.4084/mjhid.2013.065

  2701

  PDF: 840

  HTML: 14968

  Therapeutic Value of Combined Therapy with Deferasirox and Silymarin on Iron Overload in Children with Beta Thalassemia: 322

• VITAMIN D STATUS IN THALASSEMIA MAJOR: AN UPDATE

  Ashraf Tawfik Soliman

  e2013057

  2013-09-02

  https://doi.org/10.4084/mjhid.2013.057

  2755

  PDF: 1091

  HTML: 2583

• LIVER IRON CONTENT IN INDIVIDUALS WITH LIVER IRON CONTENT IN INDIVIDUALS WITH Β-THALASSEMIA TRAIT AND HYPERFERRITINEMIA: ROLE OF METABOLIC ALTERATIONS, HFE GENOTYPES, AND CIRRHOSIS.: ROLE OF METABOLIC ALTERATIONS, HFE GENOTYPES, AND CIRRHOSIS. Β-THALASSEMIA TRAIT AND HYPERFERRITINEMIA

  Alberto Piperno

  e2026051

  2026-06-30

  https://doi.org/10.4084/MJHID.2026.051

  149

  PDF: 82

  Suppl. Files: 12

  HTML: 2

• Thalassemia carrier detection among pregnant women Thalassemia carrier detection among pregnant women

  Edhyana Sahiratmadja, Merry M.V. Seu, Ita M. Nainggolan, Johanes C. Mose, Ramdan Panigoro

  e2021003

  2021-01-01

  https://doi.org/10.4084/mjhid.2021.003

  1926

  PDF: 663

  HTML: 253

• COMPARATIVE STUDY ON THE MEASUREMENT OF LIVER T2* VALUES OF THALASSEMIA PATIENTS AND THE CLINICAL GRADING OF LIVER IRON CONCENTRATION BY DIFFERENT POST-PROCESSING SOFTWARE MEASUREMENT OF LIVER T2* VALUES OF THALASSEMIA

  Peng Peng, Fengming XU, Jixing YI, Bumin LIANG, Cheng TANG, Qing FENG

  e2022072

  2022-10-29

  https://doi.org/10.4084/MJHID.2022.072

  881

  PDF: 616

  HTML: 212

• BONE MINERAL DENSITY AND VITAMIN D RECEPTOR GENETIC VARIANTS IN EGYPTIAN CHILDREN WITH BETA THALASSEMIA ON VITAMIN D SUPPLEMENTATION

  Hadeer A Abbassy, Reham Abdel Haleem Abo Elwafa, Omneya Magdy Omar

  e2019013

  2019-01-01

  https://doi.org/10.4084/mjhid.2019.013

  2289

  PDF: 1237

  HTML: 208

• BETA THALASSEMIA MAJOR IN A DEVELOPING COUNTRY: EPIDEMIOLOGICAL, CLINICAL AND EVOLUTIONARY ASPECT

  Mohamed Bejaoui, Naouel Guirat

  e2013002

  2013-01-01

  https://doi.org/10.4084/mjhid.2013.002

  1638

  PDF: 909

  HTML: 2514

• VASCULAR ENDOTHELIAL GROWTH FACTOR IN CHILDREN WITH THALASSEMIA MAJOR PDF

  sameh samir fahmey, Hassan Naguib, sanna Abdelshafy, rasha Alashry

  e2013044

  2013-06-05

  https://doi.org/10.4084/mjhid.2013.044

  1334

  PDF: 877

  HTML: 1036

  Figure 1 the correlation between frequency of blood transfusion and serum vascular endothelial growth factor (VEGF).: 183

• A MULTICENTER ICET-A STUDY ON AGE AT MENARCHE AND MENSTRUAL CYCLES IN PATIENTS WITH TRANSFUSION-DEPENDENT THALASSEMIA (TDT) WHO STARTED EARLY CHELATION THERAPY WITH DIFFERENT CHELATING AGENTS. Age at menarche and menstrual cycles in patients with transfusion-dependent thalassemia.

  SALVATORE DI MAIO, VINCENZO DE SANCTIS, PIERLUIGI MARZUILLO, CHRISTOS KATTAMIS, SHAHINA DAAR, MEHERAN KARIMI, SAKI FOROUGH, ATANAS BANKEV, VALERIA KALEVA, SOTEROULA CHRISTOU, CARMELO FORTUGNO, POLYXENI DELAPORTA, ASHRAF T SOLIMAN , PLOUTARCHOS TZOULIS

  e2023058

  2023-10-30

  https://doi.org/10.4084/MJHID.2023.058

  804

  PDF: 517

  HTML: 118

• INSULIN-LIKE GROWTH FACTOR-1 (IGF-1): DEMOGRAPHIC, CLINICAL AND LABORATORY DATA IN 120 CONSECUTIVE ADULT PATIENTS WITH THALASSAEMIA MAJOR

  V. De Sanctis

  e2014.074

  2014-11-01

  https://doi.org/10.4084/mjhid.2014.074

  2275

  PDF: 954

  HTML: 26950

• GLUCOSE HOMEOSTASIS AND ΑSSESSMENT OF Β-CELL FUNCTION BY 3-HOUR ORAL GLUCOSE TOLERANCE (OGTT) IN PATIENTS WITH Β-THALASSEMIA MAJOR WITH SERUM FERRITIN BELOW 1,000 NG/DL: RESULTS FROM A SINGLE ICET-A CENTRE OGTT in thalassemia and iron overload

  Vincenzo De Sanctis, Ashraf Soliman, Shahina Daar, Ploutarchos Tzoulis , Salvatore Di Maio, Christos Kattamis

  e2023006

  2023-01-01

  https://doi.org/10.4084/MJHID.2023.006

  3969

  PDF: 1125

  HTML: 461

• TRANSIENT ELASTOGRAPHY (TE) IS A USEFUL TOOL FOR ASSESSING THE RESPONSE OF LIVER IRON CHELATION IN SICKLE CELL DISEASE PATIENTS

  SOPHIA DELICOU

  e2018049

  2018-09-01

  https://doi.org/10.4084/mjhid.2018.049

  1581

  PDF: 832

  HTML: 196

• THE HEMATOLOGICAL PARAMETERS AND BIOCHEMICAL MARKERS OF IRON STATUS IN ALFA-THALASSEMIA 3.7KB DELETION FROM METROPOLITAN REGION OF MANAUS, AMAZONAS, BRAZIL. alfa-Thalassemia 3.7 deletion From Amazonas, Brazil.

  Fernanda Cozendey Anselmo, Abdou Gafar Soumanou , Cleidiane de Aguiar Ferreira , Flora Maia Viga Sobrinha, Ana Caroline Santos Castro, Rafael Oliveira Brito, Adolfo José Mota, Marilda de Souza Gonçalves, Jose Pereira Moura Neto

  e2021001

  2021-01-01

  https://doi.org/10.4084/MJHID.2021.001

  4156

  PDF: 622

  HTML: 401