Case Reports
Vol. 4 No. 1 (2012): Reviews, Articles, Case Reports and Letters
Tuberculosis after gastrectomy, plasmatic concentration of antitubercular drugs
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Published: January 23, 2012
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Infectious Diseases
Authors
We report pharmacokinetic data on two gastrectomized, patients affected by tuberculosis. Drugs plasmatic concentrations were measured after seven days of oral therapy by a validated high performance liquid chromatography-mass spectrometry (HPLC-MS) method and the area under the concentration-time-curve (AUC) over 24 hours (AUC0-24) was calculated. A sub-therapeutic level of isoniazid was found in a patient with total gastrectomy with a Cmax of 0,395 mg\L and AUC0-24 level of 4.75 hr*mg/L. The level of the other antitubercular drugs was adequate. Measurement of drug level in gastrectomy patients with tuberculosis is warranted.
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original articlesHow to Cite
“Tuberculosis after gastrectomy, plasmatic concentration of antitubercular drugs” (2012) Mediterranean Journal of Hematology and Infectious Diseases, 4(1), p. e2012007. doi:10.4084/mjhid.2012.007.
