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• FUNGAL INFECTIONS OF THE EAR IN IMMUNOCOMPROMISED HOST: A REVIEW

  Borlingegowda Viswanatha, Khaja Naseeruddin

  e2011003

  2011-01-04

  https://doi.org/10.4084/mjhid.2011.003

  3992

  PDF: 1684

  HTML: 3946

  Letter to Editor: 242

• RESPIRATORY VIRAL INFECTIONS IN CHILDREN AND ADOLESCENTS WITH HEMATOLOGICAL MALIGNANCIES

  Seung Beom Han, Ju Ae Shin, Seong koo Kim, Jae Wook Lee, Dong-Gun Lee, Nack-Gyun Chung, Bin Cho, Dae Chul Jeong, Jin Han Kang

  e2019006

  2019-01-01

  https://doi.org/10.4084/mjhid.2019.006

  2268

  PDF: 1302

  HTML: 273

• ANALYSIS OF PROGNOSTIC RISK FACTORS OF BLOODSTREAM INFECTIONS IN BEIJING COMMUNITIES: A RETROSPECTIVE STUDY FROM 2015 TO 2019

  Yan Liu, Beichen Cui, Chunmei Pi, Xiaohong Yu, Zhiwei Liu, Xiang Li, Liping Ma, Cong Wang

  e2021060

  2021-10-29

  https://doi.org/10.4084/MJHID.2021.060

  1001

  PDF: 456

  HTML: 186

• SURVEILLANCE AND CONTROL OF ANTIBIOTIC RESISTANCE IN THE MEDITERRANEAN REGION

  Walter Ricciardi, Gabriele Giubbini, Patrizia Laurenti

  e2016036

  2016-07-01

  https://doi.org/10.4084/mjhid.2016.036

  4330

  PDF: 1474

  HTML: 13492

• MECHANISM OF SARS-COV-2 INVASION INTO THE LIVER AND HEPATIC INJURY IN PATIENTS WITH COVID-19

  XiaoTian Zhang, Yanhui Yu, Chao Zhang, Lijuan Zhao, Hongrui Wang, Guoqing Wang, Ming Yang

  e2022003

  2022-01-01

  https://doi.org/10.4084/MJHID.2022.003

  2378

  PDF: 1214

  HTML: 438

• PROPHYLACTIC ADMINISTRATION OF DOXYCYCLINE REDUCES CENTRAL VENOUS CATHETER INFECTIONS IN PATIENTS UNDERGOING HEMATOPOIETIC CELL TRANSPLANTATION

  Mohamed Kharfan-Dabaja, Mohamed Baydoun, Zaher Otrock, Samar Okaily, Rita Nehme, Racha Abu-Chahine, Ali Hamdan, Samar Noureddine, Souha Kanj, Zeina Kanafani, Ali Bazarbachi

  e2013015

  2013-02-16

  https://doi.org/10.4084/mjhid.2013.015

  1689

  PDF: 977

  HTML: 1420

• COMPARISON OF EMPIRIC ANTIBIOTIC ESCALATION THERAPY WITH VANCOMYCIN (VAN) VERSUS LINEZOLID (LIN) IN PATIENTS WITH FEBRILE NEUTROPENIA

  Karin Mayer, Nicolaus Hegge, Ernst Molitor, Peter Brossart, Corinna Hahn-Ast

  e2022032

  2022-04-28

  https://doi.org/10.4084/MJHID.2022.032

  1261

  PDF: 632

  HTML: 274

• INVASIVE CANDIDIASIS IN NON-HEMATOLOGICAL PATIENTS.

  Malgorzata Mikulska, Matteo Bassetti, Sandra Ratto, Claudio Viscoli

  e2011007

  2011-01-25

  https://doi.org/10.4084/mjhid.2011.007

  2494

  PDF: 1048

  HTML: 11182

• A MULTICENTRE ICET-A STUDY OF CONFIRMED SARS-COV-2 INFECTION IN PATIENTS WITH HEMOGLOBINOPATHIES: PRELIMINARY DATA FROM 10 COUNTRIES

  Vincenzo De Sanctis

  e2020046

  2020-06-28

  https://doi.org/10.4084/mjhid.2020.046

  3160

  PDF: 1667

  HTML: 379

• INFECTIONS AND FOLLICULAR LYMPHOMA: IS THERE A LINK?

  Francesco Zallio, Giulia Limberti, Marco Ladetto

  e2017035

  2017-05-01

  https://doi.org/10.4084/mjhid.2017.035

  3445

  PDF: 1120

  HTML: 2603

• T-LYMPHOCYTES EXPRESSION OF TOLL-LIKE RECEPTORS 2 AND 4 IN ACUTE MYELOID LEUKEMIA PATIENTS WITH INVASIVE FUNGAL INFECTIONS Toll-like receptors 2 and 4 in Acute Myeloid Leukemia Patients with Invasive Fungal Infections

  Muhamad R. Abdel Hameed, Sherein G. Elgendy, Mohamed A El-Mokhtar, Douaa Sayed, Samar M. Mansour, Abeer M. Darwish

  e2022022

  2022-02-27

  https://doi.org/10.4084/MJHID.2022.022

  1978

  PDF: 820

  HTML: 586

• BACTERIAL BLOOD STREAM INFECTIONS NEGATIVELY IMPACT ON OUTCOME OF PATIENTS TREATED WITH ALLOGENEIC STEM CELL TRANSPLANTATION: 6 YEARS SINGLE-CENTRE EXPERIENCE

  Michele Malagola

  e2017036

  2017-06-20

  https://doi.org/10.4084/mjhid.2017.036

  4956

  PDF: 936

  HTML: 1125

• COMPARISON OF THE POWER OF PROCALCITONIN AND C-REACTIVE PROTEIN TO DISCRIMINATE BETWEEN DIFFERENT AETIOLOGIES OF FEVER IN PROLONGED PROFOUND NEUTROPENIA: A SINGLE-CENTRE PROSPECTIVE OBSERVATIONAL STUDY.

  Anke Verlinden, Veronique De Vroey, Herman Goossens, Ella Roelant, Ann Van de Velde, Zwi Berneman, Wilfried Schroyens, Alain Gadisseur

  e2019023

  2019-02-26

  https://doi.org/10.4084/mjhid.2019.023

  6924

  PDF: 1157

  HTML: 524

• TUBERCULOSIS IN TROPICAL AREAS AND IMMIGRANTS

  Lorenzo Zammarchi, Filippo Bartalesi, Alessandro Bartoloni

  e2014043

  2014-05-31

  https://doi.org/10.4084/mjhid.2014.043

  3738

  PDF: 1420

  HTML: 6370

• USE OF HEMATOPOIETIC GROWTH FACTOR IN THE MANAGEMENT OF HEMATOLOGICAL SIDE EFFECTS ASSOCIATED TO ANTIVIRAL TREATMENT FOR HCV HEPATITIS

  Paola Mancino, Katia Falasca, Claudio Ucciferri, Eligio Pizzigallo, Jacopo Vecchiet

  e2010003

  2010-03-26

  https://doi.org/10.4084/mjhid.2010.003

  1350

  PDF: 598

  HTML: 975

• THE ROLE OF CORTICOSTEROIDS IN ADULT RESPIRATORY DISTRESS SYNDROME CAUSED BY VIRIDANS GROUP STREPTOCOCCI BACTEREMIA IN NEUTROPENIC PATIENTS

  Abraham Tareq Yacoub, Lysenia Mojica, Lily Jones, Andrea Knab, Sally Alrabaa, John Norman Greene

  e2014055

  2014-09-01

  https://doi.org/10.4084/mjhid.2014.055

  2306

  PDF: 961

  HTML: 1906

  Table: 279

• Acute Cytomegalovirus infection as a cause of venous thromboembolism

  Raffaella Lissandrin, Francesco Mojoli, Fausto Baldanti, Enrico Brunetti, Michela Pascarella, Maria Teresa Giordani, Francesca Rinaldi

  e2014041

  2014-05-30

  https://doi.org/10.4084/mjhid.2014.041

  1702

  PDF: 916

  HTML: 1092

  Picture 1: 230

• CLINICAL ASPECTS OF UNCOMPLICATED AND SEVERE MALARIA

  Alessandro Bartoloni, Lorenzo Zammarchi

  e2012026

  2012-05-04

  https://doi.org/10.4084/mjhid.2012.026

  8564

  PDF: 4608

  HTML: 7618

• MANAGING INVASIVE FUNGAL INFECTIONS DURING ALLOGENEIC HEMATOPOIETIC TRANSPLANTATION: A 2025 UPDATE

  Martina Quattrone, Alessia Di Pilla, Sara Brunetti, Antonio Giordano, Luana Fianchi, Livio Pagano, Marianna Criscuolo

  e2025064

  2025-08-31

  https://doi.org/10.4084/MJHID.2025.064

  2736

  PDF: 1082

  HTML: 337

• MOLECULAR CHARACTERIZATION OF VANCOMYCIN, MUPIROCIN AND ANTISEPTIC RESISTANT STAPHYLOCOCCUS AUREUS STRAINS.

  Mahtab Hadadi, Hamid Heidari, Hadi Sedigh Ebrahim-Saraie, Mohammad Motamedifar

  e2018053

  2018-09-01

  https://doi.org/10.4084/mjhid.2018.053

  2030

  PDF: 1049

  HTML: 184

• PREVALENCE OF SERIOUS BACTERIAL INFECTIONS IN CHILDREN WITH SICKLE CELL DISEASE AT KING ABDULAZIZ HOSPITAL, AL AHSA Bacterial infections in children with sickle cell diseas

  Manal Alsaif, Joan Robinson, Moshtag Abdulbaqi, Mustafa Aghbari, Khalid Al Noaim, Muneera Alabdulqader

  e2021002

  2021-01-01

  https://doi.org/10.4084/mjhid.2021.002

  1791

  PDF: 735

  HTML: 307

• Impact of Sars-CoV-2 prophylaxis with tixagevimab-cilgavimab in high-risk patients with B-cell malignancies: a single-center retrospective study.

  Giovanni Manfredi Assanto ,, Matteo Totaro , Poggiali Rebecca, Delli Paoli Adele, Annechini Giorgia, D’Elia Gianna Maria, Aji Francesco, Petrucci Luigi, Fazio Francesca, Del Giudice Ilaria, Martelli Maurizio, Micozzi Alessandra, Giuseppe Gentile

  e2023061

  2023-10-30

  https://doi.org/10.4084/MJHID.2023.061

  1002

  PDF: 536

  HTML: 221

• PRELIMINARY STUDY OF SCD14 AND SCD163 AS PREDICTORS OF DISEASE SEVERITY AND ICU ADMISSION IN COVID-19: RELATION TO HEMATOLOGICAL PARAMETERS, BLOOD MORPHOLOGICAL CHANGES AND INFLAMMATORY BIOMARKERS

  hend Attia

  e2023046

  2023-08-29

  https://doi.org/10.4084/MJHID.2023.046

  1321

  PDF: 654

  HTML: 259

• Coexisting Pulmonary Tuberculosis and Mucormycosis in a Patient with Aplastic Anemia Post Allogenic Stem Cell Transplantion

  Sanjeev Kumar Sharma, Narendra Agrawal, Anjan Mukherjee, Tulika Seth, Pravas Mishra, Immaculata Xess, Manoranjan Mahapatra, Sanjay Sharma

  e2011036

  2011-09-08

  https://doi.org/10.4084/mjhid.2011.036

  3455

  PDF: 781

  HTML: 908

• ANTIBIOTIC LOCK THERAPY FOR PORT CATHETER-RELATED INFECTIONS OF CHILDREN WITH ACUTE LEUKEMIA

  Burçin Kurtipek; Ayça Koca Yozgat, Saliha Kanık Yüksek, Dilek Kaçar, Turan Bayhan, Dilek Gürlek Gökçebay, Aslınur Özkaya Parlak, Neşe Yaralı

  e2024072

  2024-08-31

  https://doi.org/10.4084/MJHID.2024.072

  2397

  PDF: 1167

  HTML: 450

• Bacteraemia Among Patients with Sickle Cell Disease in Nigeria: Association with Spleen Size and Function

  adama isah ladu, Mairo Usman Kadaura, Mohammed Dauda, Abubakar Sadiq Baba, Caroline Jeffery, Abubakar Farate, Adekunle Adekile, Imelda Bates, Russell Dacombe

  e2023054

  2023-08-29

  https://doi.org/10.4084/MJHID.2023.054

  960

  PDF: 590

  HTML: 210

• WHAT ARE FUNGAL INFECTIONS?

  Ben E de Pauw

  e2011001

  2011-01-03

  https://doi.org/10.4084/mjhid.2011.001

  4456

  PDF: 2533

  HTML: 27718

  de Pauw: 297

• BACTERIAL PROFILE, ANTIBIOTIC SENSITIVITY AND RESISTANCE OF LOWER RESPIRATORY TRACT INFECTIONS IN UPPER EGYPT

  Gamal Agmy, Sherif Mohamed, Yaser Gad, Essam Farghally, Hamdy Mohammedin, Hebba Rashed

  e2013056

  2013-09-02

  https://doi.org/10.4084/mjhid.2013.056

  2220

  PDF: 1595

  HTML: 3681

• CAUSAL RELATIONSHIP BETWEEN HELICOBACTER PYLORI ANTIBODIES AND IMMUNE THROMBOCYTOPENIA: A MENDELIAN RANDOMIZATION STUDY

  Yuzhan Chen, Qitian Mu, Guifang Ouyang

  e2025.003

  2024-12-31

  https://doi.org/10.4084/MJHID.2025.003

  1868

  PDF: 1361

  PDF: 960

  HTML: 378

• A Case of Rupioid Syphilis Masquerading as Aggressive Cutaneous Lymphoma

  Jonathan Braue, Thomas Hagele, Abraham Tareq Yacoub, Suganya Mannivanan, Frank Glass, Lubomir Sokol, John Norman Greene

  e2015026

  2015-04-19

  https://doi.org/10.4084/mjhid.2015.026

  2847

  PDF: 1134

  HTML: 5144

  Cover Letter: 210

  Figure 2: 217

  Figure 1: 223

  Figure 3: 248

  Figure 4: 230

  Figure Legend: 235

  Table 1: 248

  Table 2: 230

  Table 3: 225

• CHARACTERISTICS OF PATIENTS HOSPITALIZED WITH 2009 H1N1 INFLUENZA IN A TERTIARY CARE HOSPITAL IN SOUTHERN SAUDI ARABIA

  Adnan Agha, Abdul Qader Alrawi, Abdelhaleem Bella, Mohammed S. AlAyed

  e2012002

  2012-01-16

  https://doi.org/10.4084/mjhid.2012.002

  1352

  PDF: 739

  HTML: 874

• The Outcome of Six Patients with COVID-19 Infection and Multiple Myeloma. A Case Series and Literature Review COVID-19 in Multiple Myeloma patients

  Hesham Elsabah, Mahmood B. Aldabt, Ruba Taha, Dina Sameh Soliman, Halima Elomri, Feryal Ibrahim

  e2020082

  2020-10-27

  https://doi.org/10.4084/mjhid.2020.082

  1155

  PDF: 442

  HTML: 262

• EVALUATION OF USING EMPIRIC GLYCOPEPTIDES IN ACCORDANCE WITH THE IDSA GUIDELINE IN HEMATOLOGIC MALIGNANCY PATIENTS WITH FEBRILE NEUTROPENIA Empiric glycopeptide use in neutropenic fever

  Cumali Yalçın, Fahir Özkalemkaş, Vildan Özkocaman, Tuba Ersal, İbrahim Ethem Pınar, Bedrettin Orhan, Ömer Candar, Sinem Çubukçu, Tuba Güllü Koca, Merve Nur Akyol, Nevriye Gül Ada, Cüneyt Özakın, Esra Kazak, Halis Akalın, Rıdvan Ali

  e2022039

  2022-04-28

  https://doi.org/10.4084/MJHID.2022.039

  1754

  PDF: 1206

  HTML: 278

• DIAGNOSTIC VALUE OF SIMULTANEOUS MEASUREMENT OF PROCALCITONIN, INTERLEUKIN-6 AND HS CRP IN PREDICTION OF EARLY-ONSET NEONATAL SEPSIS

  alireza abdollahi, saeed shoar, fatemeh nayyeri, mamak shariat

  e2012028

  2012-05-06

  https://doi.org/10.4084/mjhid.2012.028

  2206

  PDF: 1312

  HTML: 1963

  Untitled: 194

  TaBles Neinates sepsis: 233

• CHARACTERIZATION AND ANTIMICROBIAL SUSCEPTIBILITY PROFILE OF SEPTICAEMIA-CAUSING PATHOGENS ISOLATED FROM FEBRILE CHILDREN WITH SICKLE CELL DISEASE IN KANO, NIGERIA.

  Ibrahim Yusuf

  e2018016

  2018-02-15

  https://doi.org/10.4084/mjhid.2018.016

  3087

  PDF: 1079

  HTML: 681

• BACTERIAL EPIDEMIOLOGY AND ANTIMICROBIAL RESISTANCE IN THE SURGERY WARDS OF A LARGE TEACHING HOSPITAL IN SOUTHERN ITALY

  Silvano Esposito, Renato Gioia, Giuseppe De Simone, Silvana Noviello, Sebastiano Leone

  e2015040

  2015-05-26

  https://doi.org/10.4084/mjhid.2015.040

  2391

  PDF: 1352

  HTML: 1452

• IMPORTANCE OF SOURCE CONTROL IN THE SUBGROUP OF INTRA-ABDOMINAL INFECTIONS FOR SEPTIC SHOCK PATIENTS: ANALYSIS OF 390 CASES

  Uğur Önal, Deniz Akyol, Olcay Buse Kenanoğlu, Merve Mert, Dilşah Başkol, Seichan Chousein Memetali, Gamze Şanlıdağ, Cansu Bulut, Arda Kaya, Ayşe Uyan Önal, Nazlıhan Yalçın, Günel Guliyeva, Şükrü Dirik, Oğuzhan Acet, Damla Akdağ, Melike Demir, Osman Bozbıyık, Berk Göktepe, Tufan Gümüş, İlkin Çankayalı, Kubilay Demirağ, Mehmet Uyar, Hilal Sipahi, Hüseyin Aytaç Erdem, Meltem Işıkgöz Taşbakan, Bilgin Arda, Şöhret Aydemir, Sercan Ulusoy, Oğuz Reşat Sipahi

  e2024051

  2024-06-29

  https://doi.org/10.4084/MJHID.2024.051

  1252

  PDF: 1239

  HTML: 262

• Bacillus Cereus catheter related bloodstream infection in a patient in a patient with acute lymphblastic leukemia

  Lütfiye Öksüz, N Gurler, M Muftuoglu, FD Sargin, SK Besisik

  e2012004

  2012-01-18

  https://doi.org/10.4084/mjhid.2012.004

  1825

  PDF: 1191

  HTML: 1122

• SPHINGOMONAS PAUCIMOBILIS INFECTIONS IN CHILDREN: NOSOCOMIAL VERSUS COMMUNITY ACQUIRED INFECTIONS

  Nuri Bayram, İlker Devrim, Hurşit Apa, Gamze Gülfidan, Hande Namal Türkyılmaz, İlker Günay

  e2013040

  2013-06-04

  https://doi.org/10.4084/mjhid.2013.040

  1957

  PDF: 1092

  HTML: 2093

  cover: 228

  Table 1. Co-morbidities associated with Sphingomonas paucimobilis infections.: 237

  Figure 1. The antimicrobial susceptibility patterns of Sphingomonas paucimobilis isolated from clinical specimens: 1910

  title page: 232

• INFECTIOUS RISKS AND COMPLICATIONS IN ADULT LEUKEMIC PATIENTS RECEIVING BLINATUMOMAB

  Wonhee So, Shuchi Pandya, Rod Quilitz, John Greene

  e2018029

  2018-05-01

  https://doi.org/10.4084/mjhid.2018.029

  3185

  PDF: 1181

  HTML: 390

• TUBERCULOSIS IN HEMATOPOIETIC STEM CELL TRANSPLANT PATIENTS.

  Silvia F Costa, Jessica Ramos, Marjorie Vieira Batista

  e2013061

  2013-11-04

  https://doi.org/10.4084/mjhid.2013.061

  2876

  PDF: 1057

  HTML: 3764

• Brief tale of a bacteraemia by Rhodococcus equi with concomitant lung mass: what came first, the chicken or the egg?

  Vincenzo Savini, Prassede Salutari, Marco Sborgia

  e2011006

  2011-01-17

  https://doi.org/10.4084/mjhid.2011.006

  1535

  PDF: 895

  HTML: 8689

  Fig 3 Savini: 242

  Fig 2 Savini: 240

  Fig 1 Savini Chest TC: 234

  Author letter to referees: 238

• RISK FACTORS ASSOCIATED WITH MORTALITY IN NOSOCOMIAL STENOTROPHOMONAS MALTOPHILIA PNEUMONIA: A SINGLE-CENTER RETROSPECTIVE STUDY-

  Yeşim Yıldız, Özge Özgen Top, Pınar Aysert Yıldız, Dr. Tekin Tas, Sedanur Eser, Hamid Habibi, Murat Dizbay

  e2026018

  2026-02-28

  https://doi.org/10.4084/MJHID.2026.018

  729

  PDF: 691

  HTML: 147

• COMPARISON OF PRESEPSIN, PROCALCITONIN, INTERLEUKIN-8 AND C-REACTIVE PROTEIN IN PREDICTING BACTERAEMIA IN FEBRILE NEUTROPENIC ADULT PATIENTS WITH HAEMATOLOGICAL MALIGNANCIES

  Irena Kostic, Carmela Gurrieri, Elisa Piva, Gianpietro Semenzato, Mario Plebani, Ilaria Caputo, Fabrizio Vianello

  e2019047

  2019-08-29

  https://doi.org/10.4084/mjhid.2019.047

  3777

  PDF: 1381

  HTML: 420

• INVASIVE FUNGAL INFECTIONS IN PATIENTS WITH CHRONIC LYMPHOPROLIFERATIVE DISORDERS IN THE ERA OF TARGET DRUGS

  Livio Pagano, Davide Facchinelli, Dr.

  e2018063

  2018-10-27

  https://doi.org/10.4084/mjhid.2018.063

  2217

  PDF: 1199

  HTML: 367

• VIRAL ETIOLOGY OF ACUTE RESPIRATORY INFECTIONS IN PEDIATRIC PATIENTS IN LEBANON

  Khaldoun Masoud, Ghassan Matar, Ghassan Dbaibo, Geoarge F Araj, Hasan Zaraket, Rima Hanna Wakim

  e2019059

  2019-10-30

  https://doi.org/10.4084/mjhid.2019.059

  1636

  PDF: 933

  HTML: 223

• EFFECT OF FRESH VERSUS CRYOPRESERVED GRAFTS ON FEBRILE NEUTROPENIA AND INFECTIONS IN ALLOGENEIC HEMATOPOIETIC CELL TRANSPLANTATION: FACTORS DETERMINING MORTALITY. Fresh vs Frozen Grafts: Infection and Outcome

  Cumali Yalçın, Bedrettin Orhan, Tuba Ersal, Mümin Şentürk, Vildan Özkocaman, Halis Akalın, Fahir Özkalemkaş

  e2026032

  2026-02-28

  https://doi.org/10.4084/MJHID.2026.032

  1137

  PDF: 898

  HTML: 353

• LOW INCIDENCE RATE OF OPPORTUNISTIC AND VIRAL INFECTIONS DURING IMATINIB TREATMENT IN CHRONIC MYELOID LEUKEMIA PATIENTS IN EARLY AND LATE CHRONIC PHASE

  Massimo Breccia, Corrado Girmenia, Roberto Latagliata, Giuseppina Loglisci, Michelina Santopietro, Vincenzo Federico, Luigi Petrucci, Alessandra Serrao, Adriano Salaroli, Giuliana Alimena

  e2011021

  2011-05-16

  https://doi.org/10.4084/mjhid.2011.021

  1847

  PDF: 872

  HTML: 934

  jdoe, table 2 infections CML .doc: 255

  jdoe, table 1 infections CML .doc: 233

• Epidemiology and clinical characteristics of Henoch-Schönlein purpura associated with Mycoplasma pneumoniae infection in 131 children in Hubei province, China

  hongbo Hu

  Page e2021037

  2021-04-29

  https://doi.org/10.4084/MJHID.2021.037

  1637

  PDF: 639

  HTML: 313

• IMPACT OF PRETRANSPLANT DONOR AND RECIPIENT CYTOMEGALOVIRUS SEROSTATUS ON OUTCOME FOR MULTIPLE MYELOMA PATIENTS UNDERGOING REDUCED INTENSITY CONDITIONING ALLOGENEIC STEM CELL TRANSPLANTATION.

  Jean Elcheikh

  e2013026

  2013-04-10

  https://doi.org/10.4084/mjhid.2013.026

  1426

  PDF: 801

  HTML: 1499