Vol. 18 No. 1 (2026): Mediterranean Journal of Hematology and Infectious Diseases

Published: January 1, 2026

Review Articles; Original Articles; Scientific Letters; Case Reports; Educational Clinical Cases; Letters to the Editors.

Review Articles

AGING WITH THALASSEMIA AND SICKLE CELL DISEASE: A GERONTOLOGICAL MODEL OF ACCELERATED MULTIMORBIDITY AND FUNCTION-CENTERED CARE BEYOND MIDLIFE Thalassemia and Sickle Cell Diseases: Effect of Aging

Dr.Sophia Delicou, Dr.Ioannis Ilias, Dr.Athanasia Kapota, Dr.Elena Papatheodorou, Dr.Maria Moraki, Dr.Aikaterini Xydaki, Dr.Alexandra Mika, Dr.Panagiota Giannou, Dr.Irene Kouroukli, Dr.Theodoros Aforozis, Dr.Myrto Palkopoulou, Dr.Christos Savvidis, Dr.Iliana Mani, Prof.Constantina Aggeli, Prof. John Koskinas

e2026039

https://doi.org/10.4084/MJHID.2026.039

290

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HIGHLIGHTS ON THE CONTRIBUTION OF GUT MICROBIOTA TO IMMUNE-MEDIATED DISEASES IN CHILDHOOD Gut microbiota in childhood immune-mediated diseases

Donato Rigante, Helena Pelanda, Eleonora Rulli, Murad Sultanov, Susanna Adornato

e2026025

https://doi.org/10.4084/MJHID.2026.025

1015

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COMPREHENSIVE REVIEW OF GENETIC AND EPIGENETICS REGULATION OF FETAL HEMOGLOBIN IN β-HEMOGLOBINOPATHIES: FROM MOLECULAR MECHANISMS TO CLINICAL APPLICATIONS HbF Genetics in Anemia

Yousef Saeed Mohammad Abu Za’ror, Joseph Bagi Suleiman, Fatima Azzahra Delmani, Jehad Farouq Alhmoud, Amer Mohammad Ayasreh, Sarah Ihsan Al-wendawi, Maryam Azlan

e2026046

https://doi.org/10.4084/MJHID.2026.046

299

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END-OF-LIFE CARE IN SICKLE CELL DISEASE AND TRASFUSION DEPENDEND-β-THALASSEMIA: CLINICAL, PSYCHOLOGICAL, AND ETHICAL CONSIDERATION Challenges in Supportive Care, Equity, and Compassion at End of Life

Dr. Sophia Delicou, Dr Katerina Xydaki, Dr Maria Moraki, Dr Theodoros Aforozis

e2026015

https://doi.org/10.4084/MJHID.2026.015

982

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EFFICACY AND SAFETY OF THALIDOMIDE IN PATIENTS WITH TRANSFUSION-DEPENDENT β-THALASSEMIA: A SYSTEMATIC REVIEW, META-ANALYSIS AND GRADE EVALUATION

Jialian Li, Ping Ji, Qinyue Zhong, Lin Dong, Hai Yi, Baiyu Chen, Xu Zhang, Tingting Duan

e2026033

https://doi.org/10.4084/MJHID.2026.033

172

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Original Articles

SUBTYPE DISTRIBUTION AND MUTATION SPECTRUM THALASSEMIA IN CHILDREN UNDER 10 YEARS IN NORTHERN VIETNAM

Ngoc Dung Nguyen, Ha Thanh Nguyen, Thi Chi Nguyen, Thi Nguyet Anh Phi, Thi Thu Ha Nguyen, Thi Thu Huyen Le, Phuong Linh Hoang, Duc Binh Vu

e2026002

https://doi.org/10.4084/MJHID.2026.002

904

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EVALUATION OF ORAL DOXYCYCLINE, AZITHROMYCIN, OR SEQUENTIAL DOXYCYCLINE-AZITHROMYCIN TREATMENT FOR SCRUB TYPHUS-

Hanchen Liu, Weizhen Wang, Yuqing Dong

https://doi.org/10.4084/MJHID.2026.020

616

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OPTIMIZING TREATMENT, MINIMIZING RISK: THERAPEUTIC DRUG MONITORING IN HEMATOLOGICAL MALIGNANCIES

Jon Salmanton-Garcia, Francesco Marchesi, Oliver A. Cornely, Jannik Stemler, Pierantonio Menna

https://doi.org/10.4084/MJHID.2026.022

991

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CLINICAL IMPACT OF ELTROMBOPAG-ASSOCIATED IRON CHELATION IN ADULTS WITH IMMUNE THROMBOCYTOPENIA: A MULTICENTER REAL-WORLD STUDY

Ahmet Yigitbasi, Elif Gulsum Umit, Ufuk Demirci, Guray Aygun, Nese Varli, Elif Aksoy, Fehmi Hindilerden, Emine Gulturk, Eren Arslan Davulcu, Ahmet Muzaffer Demir

https://doi.org/10.4084/MJHID.2026.027

658

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ASSOCIATION BETWEEN PRE-ADMISSION 48-HOUR FEVER BURDEN AND OUTCOMES IN PEDIATRIC MYCOPLASMA PNEUMONIAE INFECTION PRE-ADMISSION 48-HOUR FEVER BURDEN AND OUTCOMES IN PEDIATRIC MYCOPLASMA PNEUMONIAE

Lijie Ma, Ling Chen

e2026034

https://doi.org/10.4084/MJHID.2026.034

126

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RISK FACTORS ASSOCIATED WITH MORTALITY IN NOSOCOMIAL STENOTROPHOMONAS MALTOPHILIA PNEUMONIA: A SINGLE-CENTER RETROSPECTIVE STUDY-

Yeşim Yıldız, Özge Özgen Top, Pınar Aysert Yıldız, Dr. Tekin Tas, Sedanur Eser, Hamid Habibi, Murat Dizbay

e2026018

https://doi.org/10.4084/MJHID.2026.018

493

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POST-TRANSPLANT RELAPSE IN ACUTE LEUKEMIA: COMPARATIVE VALUE OF MRD AND CHIMERISM.

Sinem Başak Tan Öksüz, Güldane Cengiz Seval, Klara Dalva, Selami Koçak Toprak

https://doi.org/10.4084/MJHID.2026.028

686

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EARLY PREDICTIVE VALUE OF PERIPHERAL INFLAMMATORY INDEX COMBINED WITH HIGH-SENSITIVITY TROPONIN T FOR SEPSIS-INDUCED CARDIOMYOPATHY Inflammatory and Troponon T in cardiomyopaty from Sepsis

ChunYan Zong, FeiFeng Wu, FenFen Chen, JiaoJiao Yang, Hong Zhou, BaoFeng Zhu

e2026045

https://doi.org/10.4084/MJHID.2026.045

166

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THE IMPACT OF PRE-ANALYTICAL FACTORS ON BLOOD GLUCOSE MEASUREMENTS AND and recommendations THE IMPACT OF PRE-ANALYTICAL FACTORS ON BLOOD GLUCOSE MEASUREMENTS AND RECOMMENDATIONS FOR CLINICAL PRACTICE: AN ICET-A MULTICENTER SURVEY IN TRANSFUSION-DEPENDENT Β THALASSEMIA (Β-TDT) PATIENTS

Vincenzo De Sanctis, Christos Kattamis, Duran Canatan, Defne Ay Tuncel, Sule Unal , Dulani Kottahachchi, Mohamed A Yassin, Ashraf T Soliman, Saif Al Yaarubi , Yasser Wali, Mehran Karimi, Forough Saki, Mohammad Faranoush, Polyxeni Delaporta, Antonis Kattamis, Iskra Modeva, Ploutarchos Tzoulis, Shahina Daar, Irene Savvidou

https://doi.org/10.4084/MJHID.2026.035

181

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CD48 AS A NOVEL EARLY BIOMARKER COMPLEMENTING PROCALCITONIN AND LACTATE FOR PREDICTING BACTEREMIA IN PEDIATRIC FEBRILE NEUTROPENIA: A PROSPECTIVE COHORT STUDY CD48 A NOVEL EARLY BIOMARKER PREDICTING BACTERIEMIA

Neryal Tahta, Tuba Hilkay Karapınar, Sultan Okur Acar, Ayşe Erol, İlker Devrim, Yesim Oymak, Salih Gozmen, Canan Raziye Vergin

e2026004

https://doi.org/10.4084/MJHID.2026.004

833

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DYNAMIC MULTIPLEX CYTOKINE PROFILING TO IDENTIFY RISK FACTORS FOR LUNG CONSOLIDATION AND NECROTIZING TRANSFORMATION IN CHILDREN WITH MYCOPLASMA PNEUMONIAE PNEUMONIA

Hailiang Yan, Chuyi Zhang

e2026008

https://doi.org/10.4084/MJHID.2026.008

714

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EFFECT OF FRESH VERSUS CRYOPRESERVED GRAFTS ON FEBRILE NEUTROPENIA AND INFECTIONS IN ALLOGENEIC HEMATOPOIETIC CELL TRANSPLANTATION: FACTORS DETERMINING MORTALITY. Fresh vs Frozen Grafts: Infection and Outcome

Cumali Yalçın, Bedrettin Orhan, Tuba Ersal, Mümin Şentürk, Vildan Özkocaman, Halis Akalın, Fahir Özkalemkaş

https://doi.org/10.4084/MJHID.2026.032

781

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LUMBAR PUNCTURE: A CROSS-SECTIONAL STUDY USING THE CHINESE VERSION OF THE STATE ANXIETY SCALE FOR CHILDREN.

Xiuli Qin, Xin Zhao, Ting Zhou, Danyan Yang, Genzhen Yu

https://doi.org/10.4084/MJHID.2026.021

552

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ASSOCİATİON BETWEEN IRON OVERLOAD AND GLUCOSE METABOLİSM İN CHİLDREN AND YOUTH WİTH TRANSFUSİON-DEPENDENT BETA THALASSEMİA: THE ROLE OF CHELATİON THERAPY

Deniz Guven, Dr. İncefidan, Dr. Kazanci, Dr. Ozlem Kara

https://doi.org/10.4084/MJHID.2026.017

615

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DYNAMIC HEMOGLOBIN TRAJECTORIES IN RENAL ANEMIA AND THEIR ASSOCIATION WITH FRAILTY PROGRESSION AND CARDIOVASCULAR EVENTS IN NON‑DIALYSIS CHRONIC KIDNEY DISEASE

Li Guo, Lei Ran, Zhen-Zhen Hao, Ya-Pu Zhang, Jian-Dong Li, Shan-Shan Guo

e2026040

https://doi.org/10.4084/MJHID.2026.040

139

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DYNAMIC MONITORING OF ADAMTS 13 ACTIVITY FOR DIFFERENTIAL DIAGNOSIS ACROSS THE SPECTRUM OF SEPSIS ASSOCIATED WITH THROMBOTIC MICROANGIOPATIES Adamts 13 and Sepsis Associated with Thrombotic Thrombocytopenic Purpura

Yi Liu, Fan Lu, Binbin Ji, Wei Song, Hui Shen, Yingjie Xu, bining Yang

e2026019

https://doi.org/10.4084/MJHID.2026.019

636

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Scientific Letters

COINCIDENCE OR CONNECTION? REVISITING THE RELATIONSHIP BETWEEN MASTOCYTOSIS AND LYMPHOMA

Antonio Frolli, Cristina Papayannidis, Carmen Fava, Martina Bullo, Selene Grano, Valentina Bonuomo, Daniela Gottardi, Guido Parvis, Beatrice Casadei, Daniela Cilloni

e2026047

https://doi.org/10.4084/MJHID.2026.047

138

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Progression from Carbapenem-Resistant Enterobacterales Colonization to Bloodstream Infection in Hematopoietic Stem Cell Transplant Recipients: A Single-Center Cohort Study

Candida Diaz, Daniela Rodriguez-Feria, Javier Garzon, Oscar Muñoz

e2026041

https://doi.org/10.4084/MJHID.2026.041

135

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Ruxolitinib-Treated Myeloproliferative Neoplasms: Real-World Infectious Outcomes and Preventive Practices from a Single Center

Muruvvet Seda Aydin, Gulten Korkmaz, Merve Pamukcuoglu, Hatice Rahmet Guner, Funda Ceran, Simten Dagdas, Gulsum Ozet

https://doi.org/10.4084/MJHID.2026.044

148

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Kikuchi-Fujimoto disease and hemophagocytic lymphohistiocytosis: a rare combination of two rare diseases

Mariam Markouli, Panagiotis Diamantopoulos, Asimenia Halioti, Stavroula Lontou, Marina Mantzourani

e2026006

https://doi.org/10.4084/MJHID.2026.006

759

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Mapping Three Decades of Research on Southeast Asian Ovalocytosis: A Bibliometric Analysis

Muhd Alwi Muhd Helmi, Nor Zamzila Abdullah, Ahmad Marzuki Omar, Nour El Huda Abd Rahim, Norlelawati A. Talib

e2026036

https://doi.org/10.4084/MJHID.2026.036

106

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Simultaneous presentation of Hemophagocytic Lymphohistiocytosis and Classical Hodgkin's Lymphoma in a patient with underlying germline homozygous STXBP2 Mutation.

Dr Shilpa Gupta, Dr Amrita Rajendran , Dr Akanksha Chichra , Dr Ayubali Qureshi

e2026043

https://doi.org/10.4084/MJHID.2026.043

205

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Morphologic leukemia-free state after venetoclax-based therapy in acute myeloid leukemia is associated with high relapse despite preserved short-term survival

Kenta Motegi

e2026048

https://doi.org/10.4084/MJHID.2026.048

184

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Evaluation of Hepatitis B and C Reactivation in Chronic Myeloid Leukemia Patients Treated with Tyrosine Kinase Inhibitors

Nathalia Sena de Oliveira Silva, Gislaine Duarte, Samuel de Souza Medina, Guilherme Brasil Duffles Amarante, Carmino Antonio de Souza, Katia Borgia Barbosa Pagnano

e2026001

https://doi.org/10.4084/MJHID.2026.001

643

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Acute Hemolytic Anemia Following Rasburicase in a Very Late Post-Transplant Relapse of Acute Myeloid Leukemia

Gianluca Cavallaro, Federico Lussana, Marco Frigeni, Maria Caterina Micò, Alessandra Algarotti, Anna Grassi, Orietta Spinelli, Chiara Pavoni, Elena Oldani, Alessandro Rambaldi

e2026003

https://doi.org/10.4084/MJHID.2026.003

560

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Concordance Rate of Fasting Plasma Glucose (PG) and 2-hour PG post Oral Glucose Tolerance Test (OGTT) in Patients with new diagnosis of Thalassemia-Related Diabetes Mellitus (Th-RDM):Implications for Clinical Practice OGTT concordance rate in thalassemia major

Vincenzo De Sanctis, Mohammad Faranoush, Shahina Daar, Ihab Elhakim, Ashraf T Soliman, Forough Saki, Mehran Karimi, Ploutarchos Tzoulis

e2026011

https://doi.org/10.4084/MJHID.2026.011

582

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Clinical and Hematological Characteristics of Vietnamese Heterozygous Hb Tak/β-Thalassemia Patients: A Four- Case Series

Ngoc Dung Nguyen, Thi Chi Nguyen, Thi Thu Ha Nguyen, Thi Nguyet Anh Phi, Xuan Hai Le, Duc Luong Vu

e2026024

https://doi.org/10.4084/MJHID.2026.24

487

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Counting the Cost: How Anticipating Financial Burden Affects Post-Traumatic Stress Symptoms in Patients Newly Diagnosed with Leukemia and Lymphoma

Fabio Guolo, Paola Del Sette, Francesca Riccardi, Paola Minetto, Andrea Todiere, Filippo Ballerini, Carola Riva, Michele Cea, Roberto Massimo Lemoli, Elena Sarcletti

https://doi.org/10.4084/MJHID.2026.029

409

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Successful Treatment with Imipenem/Cilastatin/Relebactam of a Polymicrobial Bacteremia due to Meropenem/Vaborbactam-Resistant KPC-Producing Klebsiella pneumoniae and Enterococcus faecalis

Federico Marzi, Mario Alessandri, Veronica De Crescenzo, Stefania Del Vecchio, Simone Radi, Maurizio Manini

e2026037

https://doi.org/10.4084/MJHID.2026.037

177

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Early Diagnosis of Gaucher Disease and ASMD in Sardinia: the “ICHNOS” Project

Daniela Perra, Carmela Zizzo, Olga Mulas, Luigi Podda, Francesco Longu, Claudio Fozza, Angelo Palmas, Luigi Curreli, Alessandro Costa, Maria Domenica Cappellini, Giovanni Caocci

e2026016

https://doi.org/10.4084/MJHID.2026.016

611

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CD56⁺/CD38⁺ Neutrophils: Rapid and Specific Flow Cytometric Signature for Chronic Myeloid Leukemia

Alessandro Laganà, Matteo Breccia, Loredana Elia, Emilia Scalzulli, Maria Laura Bisegna, Claudia Ielo, Sonia Buffolino, Attilio Di Lascio, Concetta Anna Germano, Stefania Intoppa, Maria Laura Milani, Maurizio Martelli, Massimo Breccia, Maria Stefania De Propris

https://doi.org/10.4084/MJHID.2026.049

145

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Validation of a New Scoring System for Treatment Failure in CML Patients on Tyrosine Kinase Inhibitors in a real world setting

Andrea Mattozzi, Eugenio Galli, Francesco Autore, Ilaria Pansini, Patrizia Chiusolo, Simona Sica, Federica Sorà

e2026013

https://doi.org/10.4084/MJHID.2026.013

561

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The Splenectomy Paradox in Thalassemia: Reduced Transfusion Requirements vs. Accelerated Hepatic Fibrogenesis

Padmapani Padeniya, Dileepa Ediriweera, Madunil Niriella, Arjuna De Silva, Dulani Kottahachchi, Anuja Premawardhena

https://doi.org/10.4084/MJHID.2026.023

513

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Immune Biomarker Signature in the Diagnostic Workup of Fever Without Source: A Pilot Study

Angela Maria Di Francesco, Giuliana Pasciuto, Laura Gerardino, Ludovico Luca Sicignano, Elena Verrecchia, Andrea Urbani, Donato Rigante, Raffaele Manna

https://doi.org/10.4084/MJHID.2026.030

450

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MJHID Educational Clinical Cases

Atypical evolution of a Vaso-Occlusive presentation in Sickle Cell Disease: lessons in diagnostic vigilance

Cristina Giubbilei, Elena Angeli, Fiammetta Fossi, Agnese Baffioni, Ginevra Giustini, Valentina Carrai

https://doi.org/10.4084/MJHID.2026.042

113

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Letters to the Editor

Hematogenous Disseminated Pulmonary Tuberculosis in an Elderly Patient with Acute Myeloid Leukemia: A Case Report

Yu xi Ding, Xiao Dong Liu, wenqiang kong

e2026010

https://doi.org/10.4084/MJHID.2026.010

519

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Acquired CD20 Loss as a Mechanism of Resistance to Mosunetuzumab in Relapsed Follicular Lymphoma

Martina Canichella, Stefano Fratoni, Carla Mazzone, alice di rocco, elisabetta abruzzese

e2026014

https://doi.org/10.4084/MJHID.2026.014

748

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Psychiatric Symptoms after H1N1 Influenza Treated with Baloxavir Marboxil in Two Patients with Hematologic Malignancies

Zhan Su, Xiaojia Bu, Yao Li

https://doi.org/10.4084/MJHID.2026.031

516

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Young Chronic Lymphocytic Leukemia Patient with Cat Scratch Disease Diagnosed via Next-Generation Sequencing

Chengxin Luan, Xiuping Yang, Linlin Dong, Ying Zhu, Hongguo Zhao

e2026007

https://doi.org/10.4084/MJHID.2026.007

571

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Leukemia cutis as a transient alarm bell of disease progression in a patient with chronic lymphocytic leukemia under watchful waiting

Simone Landini, Alberto Corrà, Alessandro Sanna, Gioia Di Stefano, Raffaella Santi, Marzia Caproni, Alice Verdelli

e2026012

https://doi.org/10.4084/MJHID.2026.012

527

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OMENTAL SPLENOSIS MIMICKING PERITONEAL CARCINOMATOSIS

Andrea Piccin

e2026038

https://doi.org/10.4084/MJHID.2026.038

91

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Community-acquired Carbapenem-resistant Escherichia coli Bacteremia Complicated by c: A Case Report

Yu Chen, Jin Zhang, wenqiang kong

e2026005

https://doi.org/10.4084/MJHID.2026.005

521

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Pathogenetic mechanism of macular edema during a treatment with ibrutinib: a case presentation.

Cristina Mauro, Livio Pupo, Lucia Cardillo, Fabiana Esposito, Elisa Buzzatti, Marco Lombardo, Massimo Cesareo, Adriano Venditti, Massimiliano Postorino, Maria Ilaria Del Principi

e2026009

https://doi.org/10.4084/MJHID.2026.009

543

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Seven-Year Course of Hypoplastic Myelodysplastic Syndrome Unmasked by Secondary and Neurosyphilis.

Ali Turunç, Hüseyin Derya Dinçyürek, Birol Güvenç

e2026026

https://doi.org/10.4084/MJHID.2026.026

459

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Current Issue

Vol. 18 No. 1 (2026): Mediterranean Journal of Hematology and Infectious Diseases

Review Articles

AGING WITH THALASSEMIA AND SICKLE CELL DISEASE: A GERONTOLOGICAL MODEL OF ACCELERATED MULTIMORBIDITY AND FUNCTION-CENTERED CARE BEYOND MIDLIFE Thalassemia and Sickle Cell Diseases: Effect of Aging

HIGHLIGHTS ON THE CONTRIBUTION OF GUT MICROBIOTA TO IMMUNE-MEDIATED DISEASES IN CHILDHOOD Gut microbiota in childhood immune-mediated diseases

COMPREHENSIVE REVIEW OF GENETIC AND EPIGENETICS REGULATION OF FETAL HEMOGLOBIN IN β-HEMOGLOBINOPATHIES: FROM MOLECULAR MECHANISMS TO CLINICAL APPLICATIONS HbF Genetics in Anemia

END-OF-LIFE CARE IN SICKLE CELL DISEASE AND TRASFUSION DEPENDEND-β-THALASSEMIA: CLINICAL, PSYCHOLOGICAL, AND ETHICAL CONSIDERATION Challenges in Supportive Care, Equity, and Compassion at End of Life

Original Articles

ASSOCIATION BETWEEN PRE-ADMISSION 48-HOUR FEVER BURDEN AND OUTCOMES IN PEDIATRIC MYCOPLASMA PNEUMONIAE INFECTION PRE-ADMISSION 48-HOUR FEVER BURDEN AND OUTCOMES IN PEDIATRIC MYCOPLASMA PNEUMONIAE

EARLY PREDICTIVE VALUE OF PERIPHERAL INFLAMMATORY INDEX COMBINED WITH HIGH-SENSITIVITY TROPONIN T FOR SEPSIS-INDUCED CARDIOMYOPATHY Inflammatory and Troponon T in cardiomyopaty from Sepsis

CD48 AS A NOVEL EARLY BIOMARKER COMPLEMENTING PROCALCITONIN AND LACTATE FOR PREDICTING BACTEREMIA IN PEDIATRIC FEBRILE NEUTROPENIA: A PROSPECTIVE COHORT STUDY CD48 A NOVEL EARLY BIOMARKER PREDICTING BACTERIEMIA

EFFECT OF FRESH VERSUS CRYOPRESERVED GRAFTS ON FEBRILE NEUTROPENIA AND INFECTIONS IN ALLOGENEIC HEMATOPOIETIC CELL TRANSPLANTATION: FACTORS DETERMINING MORTALITY. Fresh vs Frozen Grafts: Infection and Outcome

DYNAMIC MONITORING OF ADAMTS 13 ACTIVITY FOR DIFFERENTIAL DIAGNOSIS ACROSS THE SPECTRUM OF SEPSIS ASSOCIATED WITH THROMBOTIC MICROANGIOPATIES Adamts 13 and Sepsis Associated with Thrombotic Thrombocytopenic Purpura

Scientific Letters

Concordance Rate of Fasting Plasma Glucose (PG) and 2-hour PG post Oral Glucose Tolerance Test (OGTT) in Patients with new diagnosis of Thalassemia-Related Diabetes Mellitus (Th-RDM):Implications for Clinical Practice OGTT concordance rate in thalassemia major

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