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• IMPACT OF COVID-19 ON OUTCOMES OF PATIENTS WITH HEMATOLOGIC MALIGNANCIES: A MULTI-CENTER, RETROSPECTIVE STUDY COVID-19 and hematologic malignancy

  İbrahim Halil Açar, Sebnem Izmir Güner , Muzeyyen Aslaner Ak, Mesut Gocer, Erman Ozturk , Figen Atalay, Gulden Sincan , Aysun Senturk Yikilmaz, Omer Ekinci, Idris Ince, Emine Gulturk , Nazli Demir, Ali Dogan, Yildiz Ipek, Birol Guvenc

  e2022074

  2022-10-29

  https://doi.org/10.4084/MJHID.2022.074

  1458

  PDF: 761

  HTML: 199

• ESCHERICHIA COLI: AN IMPORTANT PATHOGEN IN PATIENTS WITH HEMATOLOGIC MALIGNANCIES

  Daniel Olson, Abraham Tareq Yacoub, Gelenis Domingo, John Norman Greene

  e2014068

  2014-08-28

  https://doi.org/10.4084/mjhid.2014.068

  1812

  PDF: 709

  HTML: 2100

  Untitled: 211

  Untitled: 151

  Untitled: 167

  Untitled: 152

  Untitled: 160

  Untitled: 174

  Untitled: 182

• CLONAL HEMATOPOIESIS: ROLE IN HEMATOLOGIC NON-HEMATOLOGIC MALIGNANCIES CLONAL HEMATOPOIESIS AND MALIGNANCIES

  Ugo Testa, Dr. Germana Castelli, Dr. Elvira Pelosi

  e2022069

  2022-08-27

  https://doi.org/10.4084/MJHID.2022.069

  2914

  PDF: 882

  HTML: 1736

• THE ROLE OF WHITE BLOOD CELL COUNT IN PERIANAL PATHOLOGIES: A RETROSPECTIVE ANALYSIS OF HEMATOLOGIC MALIGNANCIES Role of white blood cell count in perianal pathologies

  Bedrettin Orhan, Fahir Özkalemkaş, Vildan Özkocaman, Büşra Gürbüz, Tuba Ersal, İbrahim Ethem Pınar, Cumali Yalçın, Ömer Candar, Sinem Çubukçu, Tuba Güllü Koca, Rıdvan Ali

  e2022051

  2022-06-29

  https://doi.org/10.4084/MJHID.2022.051

  3031

  PDF: 1839

  HTML: 231

• THE IMPACT OF CHEMOTHERAPY AFTER PEDIATRIC MALIGNANCY ON HUMORAL IMMUNITY TO VACCINE-PREVENTABLE DISEASES

  Chiara Garonzi, Rita Balter, Gloria Tridello, Anna Pegoraro, Manuela Pegoraro, Monia Pacenti, Novella Scattolo, Simone Cesaro

  e2020014

  2020-02-26

  https://doi.org/10.4084/mjhid.2020.014

  1572

  PDF: 972

  HTML: 275

• Human T-cell leukemia virus type ? associated with an increased risk of primary malignant neoplasm

  Aya Nakaya, Shinya Fujita, Atsushi Satake, Takahisa Nakanishi, Yoshiko Azuma, Yukie Tsubokura, Akiko Konishi, Masaaki Hotta, Hideaki Yoshimura, Kazuyoshi Ishii, Tomoki Ito, Shosaku Nomura

  e2018024

  2018-04-20

  https://doi.org/10.4084/mjhid.2018.024

  2249

  PDF: 725

  HTML: 297

• ZYGOMYCOSIS IN IMMUNOCOMPROMISED NON-HAEMATOLOGICAL PATIENTS

  George Petrikkos, Miranda Drogari-Apiranthitou

  e2011012

  2011-03-14

  https://doi.org/10.4084/mjhid.2011.012

  2796

  PDF: 940

  HTML: 7328

• EVALUATION OF USING EMPIRIC GLYCOPEPTIDES IN ACCORDANCE WITH THE IDSA GUIDELINE IN HEMATOLOGIC MALIGNANCY PATIENTS WITH FEBRILE NEUTROPENIA Empiric glycopeptide use in neutropenic fever

  Cumali Yalçın, Fahir Özkalemkaş, Vildan Özkocaman, Tuba Ersal, İbrahim Ethem Pınar, Bedrettin Orhan, Ömer Candar, Sinem Çubukçu, Tuba Güllü Koca, Merve Nur Akyol, Nevriye Gül Ada, Cüneyt Özakın, Esra Kazak, Halis Akalın, Rıdvan Ali

  e2022039

  2022-04-28

  https://doi.org/10.4084/MJHID.2022.039

  1437

  PDF: 1048

  HTML: 213

• THERAPY-RELATED MYELOID NEOPLASM IN NON-HODGKIN LYMPHOMA SURVIVORS

  Alessia Bari, Luigi Marcheselli, Raffaella Marcheselli, Eliana Valentina Liardo, Samantha Pozzi, Stefano Sacchi

  e2011065

  2011-12-20

  https://doi.org/10.4084/mjhid.2011.065

  2560

  PDF: 734

  HTML: 2295

• INFLUENZA AND PNEUMOCOCCAL VACCINATION IN HEMATOLOGICAL MALIGNANCIES: A SYSTEMATIC REVIEW OF EFFICACY, EFFECTIVENESS AND SAFETY

  Giuseppe La Torre

  e2016044

  2016-09-01

  https://doi.org/10.4084/mjhid.2016.044

  4663

  PDF: 1464

  HTML: 3139

• MANAGEMENT OF LATENT TUBERCULOSIS INFECTION BASED ON T-SPOT.TB ASSAY IN PATIENTS WITH HEMATOLOGICAL MALIGNANCIES

  Emrah Kiliacaslan, Kadir Canoglu

  e2023003

  2022-12-31

  https://doi.org/10.4084/MJHID.2023.003

  1411

  PDF: 1105

  HTML: 467

• GENETIC PREDISPOSITION TO HEMATOLOGIC MALIGNANCIES IN CHILDHOOD AND ADOLESCENCE

  Francesco Fabozzi, Angela Mastronuzzi

  e2023032

  2023-04-28

  https://doi.org/10.4084/MJHID.2023.032

  1903

  PDF: 501

  HTML: 534

• THERAPY-RELATED MYELOID NEOPLASMS IN PATIENTS TREATED FOR HODGKIN LYMPHOMA

  Dennis A Eichenauer, Andreas Engert

  e2011046

  2011-10-24

  https://doi.org/10.4084/mjhid.2011.046

  2251

  PDF: 748

  HTML: 1198

• EBV-RELATED LYMPHOPROLIFERATIVE DISEASES: A REVIEW IN LIGHT OF NEW CLASSIFICATIONS EBV-RELATED LYMPHOPROLIFERATIVE DISEASES

  Pietro Tralongo, Arianna Bakacs, Luigi Maria Larocca

  e2024042

  2024-04-30

  https://doi.org/10.4084/MJHID.2024.042

  4075

  PDF: 1576

  HTML: 932

• CLASSIC KSHV/HHV-8-POSITIVE PRIMARY EFFUSION LYMPHOMA (PEL): A SYSTEMATIC REVIEW AND META-ANALYSIS OF CASE REPORTS

  Ilaria Cozzi, Giovanni Rossi, Emma Rullo, Valeria Ascoli

  e2022020

  2022-02-27

  https://doi.org/10.4084/MJHID.2022.020

  1519

  PDF: 938

  HTML: 296

• Simultaneous presentation of Hemophagocytic Lymphohistiocytosis and Classical Hodgkin's Lymphoma in a patient with underlying germline homozygous STXBP2 Mutation.

  Dr Shilpa Gupta, Dr Amrita Rajendran , Dr Akanksha Chichra , Dr Ayubali Qureshi

  e2026043

  2026-04-30

  https://doi.org/10.4084/MJHID.2026.043

  189

  PDF: 128

  HTML: 12

• Idiopathic pulmonary embolism in a case of severe family ANKRD26 thrombocytopenia

  Jérôme Guison, Gilles Blaison, Oana Stoica, Remy Hurstel, Marie Favier, Remi Favier

  e2017038

  2017-06-16

  https://doi.org/10.4084/mjhid.2017.038

  2128

  PDF: 826

  HTML: 923

  Patient’s family tree: 164

• NUTRITIONALLY VARIANT STREPTOCOCCI BACTEREMIA IN CANCER PATIENTS: A RETROSPECTIVE STUDY, 1999-2014

  Abraham Tareq Yacoub, Jayasree Krishnan, Ileana M. Acevedo, Joseph Halliday, John Norman Greene

  e2015030

  2015-04-19

  https://doi.org/10.4084/mjhid.2015.030

  2079

  PDF: 983

  HTML: 4067

  Cover Letter: 218

  Figure 1: 226

  Figure 2: 227

  Table 1: 201

• PROTECTIVE ROLE OF SYLIMARIN ON METHOTREXATE INDUCED HEPATO-NEPHROTOXICITY IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA

  Adel Abd Elhaleim Hagag

  e2016043

  2016-09-01

  https://doi.org/10.4084/mjhid.2016.043

  3577

  PDF: 1024

  HTML: 1288

• THE ROLE OF CORTICOSTEROIDS IN ADULT RESPIRATORY DISTRESS SYNDROME CAUSED BY VIRIDANS GROUP STREPTOCOCCI BACTEREMIA IN NEUTROPENIC PATIENTS

  Abraham Tareq Yacoub, Lysenia Mojica, Lily Jones, Andrea Knab, Sally Alrabaa, John Norman Greene

  e2014055

  2014-09-01

  https://doi.org/10.4084/mjhid.2014.055

  2055

  PDF: 850

  HTML: 1848

  Table: 225

• COVID-19 IN CHILDREN AND ADOLESCENT: CHARACTERISTICS AND SPECIFICITIES IN IMMUNOCOMPETENT AND ONCOHEMATOLOGICAL PATIENTS COVID-19 IN CHILDREN AND ADOLESCENT.

  Federico Mercolini, Simone Cesaro

  e2022009

  2022-01-01

  https://doi.org/10.4084/MJHID.2022.009

  2225

  PDF: 930

  HTML: 298

• DIAGNOSIS AND SUBCLASSIFICATION OF ACUTE LYMPHOBLASTIC LEUKEMIA

  Sabina Chiaretti, Gina Zini, Renato Bassan

  e2014073

  2014-10-24

  https://doi.org/10.4084/mjhid.2014.073

  9022

  PDF: 6043

  HTML: 87937

  Fig.1b: 182

  Fig.1c: 186

  Fig.2a: 174

  Fig.2b: 173

  Fig.4: 186

  Fig.2c: 181

  Fig.3: 179

  Tab.1: 225

  Tab.2: 205

  Tab.3: 188

  Tab.4: 220

  Fig1a: 179

• Bordetella Bronchiseptica in the Immunosuppressed Population – A Case Series and Review.

  Abraham Tareq Yacoub, Mitsuya Katayama, JoAnn Tran, Ronit Zadikany, Manasa Kandula, John Norman Greene

  e2014031

  2014-04-06

  https://doi.org/10.4084/mjhid.2014.031

  2431

  PDF: 1293

  HTML: 1743

  CoverLetter: 176

• OUTBREAK OF BURKHOLDERIA CEPACIA INFECTION: A SYSTEMATIC STUDY IN A HEMATOLOGY-ONCOLOGY UNIT OF A TERTIARY CARE HOSPITAL FROM EASTERN INDIA.

  Shuvra Neel Baul, Rajib De, PRAKAS KUMAR MANDAL, Swagnik Roy, Tuphan Kanti Dolai, Prantar Chakrabarti

  e2018051

  2018-09-01

  https://doi.org/10.4084/mjhid.2018.051

  2167

  PDF: 922

  HTML: 405

  Outbreak of Burkholderia cepacia infection: a systematic study in a hematolo-oncology unit of a tertiary care hospital from Eastern India: 211

  UntitOutbreak of Burkholderia cepacia infection: a systematic study in a hematolo-oncology unit of a tertiary care hospital from Eastern Indialed: 339

  Outbreak of Burkholderia cepacia infection: a systematic study in a hematolo-oncology unit of a tertiary care hospital from Eastern India: 237

  Outbreak of Burkholderia cepacia infection: a systematic study in a hematolo-oncology unit of a tertiary care hospital from Eastern India: 176

  Outbreak of Burkholderia cepacia infection: a systematic study in a hematolo-oncology unit of a tertiary care hospital from Eastern India: 188

  Outbreak of Burkholderia cepacia infection: a systematic study in a hematolo-oncology unit of a tertiary care hospital from Eastern India: 256

• DIAGNOSTIC VALUE OF BRONCHOALVEOLAR LAVAGE IN LEUKEMIC AND BONE MARROW TRANSPLANT PATIENTS: THE IMPACT OF ANTIMICROBIAL THERAPY

  John Norman Greene, Abraham Tareq Yacoub, Dani Thomas, Carol Yuan, Frank Walsh, David Solomon, Skai Schwartz, Arthur Andrews

  e2015002

  2014-12-19

  https://doi.org/10.4084/mjhid.2015.002

  1940

  PDF: 817

  HTML: 2194

  Table 1: 174

  Table 2: 193

  Table 3: 186

  Table 4: 188

  Table 5: 186

  Tble 6: 179

  Cover Letter: 200

  Greene Tab.7: 185

• TOXICITIES ASSOCIATED WITH CAR-T CELL THERAPIES CAR-T Cell Toxicity

  Ugo Testa, Dr. Germana Castelli, Dr. Elvira Pelosi, Dr. Galli, Prof. Patrizia Chiusolo

  e2025039

  2025-04-30

  https://doi.org/10.4084/MJHID.2025.039

  2153

  PDF: 1466

  HTML: 262

• A MULTICENTER EXPERIENCE FROM LEBANON IN CHILDHOOD AND ADOLESCENT ACUTE MYELOID LEUKEMIA:HIGH RATE OF EARLY DEATH IN CHILDHOOD ACUTE PROMYELOCYTIC LEUKEMIA.

  Roula Antoine Farah

  e2015012

  2014-12-27

  https://doi.org/10.4084/mjhid.2015.012

  2057

  PDF: 1109

  HTML: 7689

  cover letter paper final AML: 213

• TP53-MUTATED MYELODYSPLASIA AND ACUTE MYELOID LEUKEMIA TP53 in MDS and AML

  Ugo Testa, Dr. Germana Castelli, Dr. Elvira Pelosi

  e2023038

  2023-06-29

  https://doi.org/10.4084/MJHID.2023.038

  2081

  PDF: 1666

  HTML: 371

• Bilateral Pleural Effusions due to Pulmonary Amyloidosis as the Presenting Manifestation of Multiple Myeloma

  Abhishek Agarwal, Sandeep Singla, Meghana Bansal, Bijay Nair

  e2012010

  2012-01-25

  https://doi.org/10.4084/mjhid.2012.010

  1263

  PDF: 758

  HTML: 4369

  Figure 1: 152

  Untitled: 126

  Untitled: 178

• SUCCESSFUL LONG TERM ERADICATION OF FACTOR VIII INHIBITOR IN PATIENTS WITH ACQUIRED HAEMOPHILIA A IN SAUDI ARABIA

  Galila F Zaher, Soheir S Adam

  e2012021

  2012-04-02

  https://doi.org/10.4084/mjhid.2012.021

  1280

  PDF: 891

  HTML: 3592

• ASSESSMENT OF CONGENITAL NEUTROPENIA IN CHILDREN: COMMON CLINICAL SCENERIES AND CLUES FOR MANAGEMENT Assessment of congenital neutropenia in children

  Ilaria Lazzareschi, Elena Rossi, Antonietta Curatola, Giovanna Capozio, Luca Benacquista, Ludovica Iezzi, Donato Rigante

  e2022008

  2022-01-01

  https://doi.org/10.4084/MJHID.2022.008

  1972

  PDF: 1118

  HTML: 614

• AUTOLOGOUS STEM CELL TRANSPLANTATION FOR CHRONIC LYMPHOCYTIC LEUKEMIA STILL A VALID TREATMENT OPTION, OR IS THE GAME OVER ?

  Fabienne McClanahan, Peter Dreger

  e2012071

  2012-11-06

  https://doi.org/10.4084/mjhid.2012.071

  2410

  PDF: 804

  HTML: 1664

• INVASIVE FUNGAL INFECTIONS IN PATIENTS WITH CHRONIC LYMPHOPROLIFERATIVE DISORDERS IN THE ERA OF TARGET DRUGS

  Livio Pagano, Davide Facchinelli, Dr.

  e2018063

  2018-10-27

  https://doi.org/10.4084/mjhid.2018.063

  2022

  PDF: 1111

  HTML: 178

• COMPARISON OF ANTIMICROBIAL SENSITIVITY TO OLDER AND NEWER QUINOLONES VERSUS PIPERACILLIN-TAZOBACTAM, CEFEPIME AND MEROPENEM IN FEBRILE PATIENTS WITH CANCER IN TWO REFERRAL PEDIATRIC CENTERS IN TEHRAN, IRAN

  Ali Nateghian, Joan Robinson, P. Vosough, M. Navidinia, M. Malekanl, A. Mehrvar, B. Sobuti, Pooria Bahadoran, Z. Gholinejad

  e2014045

  2014-06-29

  https://doi.org/10.4084/mjhid.2014.045

  1285

  PDF: 701

  HTML: 2292

  Cover Letter: 184

• PLASMABLASTIC LYMPHOMA. A STATE-OF-THE-ART REVIEW (1) Part 1- Epidemiology, pathogenesis, clinicopathologic characteristics, differential diagnosis, prognostic factors and special populations

  Michele Bibas

  e2024007

  2024-01-01

  https://doi.org/10.4084/MJHID.2024.007

  3530

  PDF: 2393

  HTML: 1454

• WALDENSTRÖM MACROGLOBULINEMIA - A STATE-OF-THE-ART REVIEW: PART 1: EPIDEMIOLOGY, PATHOGENESIS, CLINICOPATHOLOGIC CHARACTERISTICS, DIFFERENTIAL DIAGNOSIS, RISK STRATIFICATION, AND CLINICAL PROBLEMS

  Michele Bibas, Shayna Sarosiek, Jorge J. Castillo

  e2024061

  2024-06-29

  https://doi.org/10.4084/MJHID.2024.061

  2711

  PDF: 3187

  HTML: 365

• THERAPY-RELATED MYELOID NEOPLASMS: PREDISPOSITION AND CLONAL EVOLUTION T-AML predisposition

  Emiliano Fabiani, Dr. Falconi, Dr. Cristiano, Dr. Hajrullaj, Dr. Falconi, Prof. Leone, Prof. Voso

  e2023064

  2023-10-30

  https://doi.org/10.4084/MJHID.2023.064

  1317

  PDF: 814

  HTML: 125

• PERSISTENT COLONIC SCHISTOSOMIASIS AMONG SYMPTOMATIC RURAL INHABITANTS IN THE EGYPTIAN NILE DELTA Colonic schistosomiasis among rurals of the Egyptian Nile delta

  Mohamed Emara, Middle name: Hussien, Dr, Middle name: Asem, Dr, Prof., Prof., Dr.

  Page e2021033

  2021-04-29

  https://doi.org/10.4084/mjhid.2021.033

  1499

  PDF: 474

  MP4: 402

  Html: 192

• A case of central venous catheter-related Candida parapsilosis fungemia evolved to disseminated infection in a neutropenic patient with blast crisis of chronic myeloid leukemia.

  Elena Amabile, Matteo Totaro, Luca Cappelli, Clara Minotti, Alessandra Micozzi

  e2024013

  2024-01-01

  https://doi.org/10.4084/MJHID.2024.013

  895

  PDF: 1167

  HTML: 150

• Monoclonal Gammopathy of Undetermined Significance Disguised as Chronic Neutrophilic Leukemia

  Monique A Hartley-Brown, Lubomir Sokol, Gisela L Caceres, Mohammed A Hussein, Alan List, Javier Pinilla-Ibarz

  e2010002

  2010-02-23

  https://doi.org/10.4084/mjhid.2010.002

  1023

  PDF: 549

  HTML: 393

• EARLY APPLICATION OF HIGH CUT-OFF HAEMODYALISIS FOR DE-NOVO MYELOMA NEPHROPATHY IS ASSOCIATED WITH LONG-TERM DIALYSIS-INDEPENDENCY AND RENAL RECOVERY

  Alhossain A. Khalafallah, Sie Wuong Loi, Sarah Love, Muhajir B. Mohamed, Rose Mace, Ramy Khalil, Miriam Girgs, Rajesh Raj, Mathew Mathew

  e2013007

  2013-01-02

  https://doi.org/10.4084/mjhid.2013.007

  1331

  PDF: 652

  HTML: 2498

  cover letter: 192

• The THE PLASMABLASTIC LYMPHOMA. A STATE-OF-THE-ART REVIEW: PART 2-FOCUS ON THERAPY

  Michele Bibas

  e2024015

  2024-02-29

  https://doi.org/10.4084/MJHID.2024.015

  1689

  PDF: 1653

  HTML: 794

• RISK FACTORS ASSOCIATED WITH MORTALITY IN NOSOCOMIAL STENOTROPHOMONAS MALTOPHILIA PNEUMONIA: A SINGLE-CENTER RETROSPECTIVE STUDY-

  Yeşim Yıldız, Özge Özgen Top, Pınar Aysert Yıldız, Dr. Tekin Tas, Sedanur Eser, Hamid Habibi, Murat Dizbay

  e2026018

  2026-02-28

  https://doi.org/10.4084/MJHID.2026.018

  484

  PDF: 343

  HTML: 70

• THE SPECTRUM OF HYPEREOSINOPHILIA AND ASSOCIATED CLONAL DISORDERS – A REAL WORLD DATA FROM A TROPICAL SETTING.

  Sreejesh Sreedharanunni, Neelam Varma, Man Updesh Singh Sachdeva, Shano Naseem, Pankaj Malhotra, Deepak Bansal, Amita Trehan, Subhash Varma

  e2018052

  2018-09-01

  https://doi.org/10.4084/mjhid.2018.052

  1845

  PDF: 944

  HTML: 517

• BASELINE THROMBIN GENERATION TEST DOES NOT PREDICT THROMBOTIC EVENTS IN ACUTE LEUKEMIA: A MONOCENTRIC PROSPECTIVE STUDY

  Mario Biglietto, Rosaria Mormile, Maria Laura Bisegna, Alessandro Laganà, Anna Laura Faccini, Andrea Papa, Erminia Baldacci, Cristina Santoro, Maria Stefania De Propris, Antonio Chistolini

  e2025076

  2025-10-31

  https://doi.org/10.4084/MJHID.2025.076

  384

  PDF: 181

  Html: 44

• Internal Medicine Ward with Hematological Skills for the Treatment of Complications Suffered by Hematological Patients on Therapy: Experience of Villa Betania Hospital inRome

  alessandro andriani, Laura Marchetti, Fabio Rossi, Silvia Raja, Maria Antonietta Perretti, Umberto Recine

  e2024030

  2024-02-29

  https://doi.org/10.4084/MJHID.2024.030

  600

  PDF: 1025

  HTML: 93

• Ceftolozane-Tazobatam for febrile neutropenia treatment in hematologic malignancy patients colonized by multi-resistant Enterobacteriaceae: preliminary results from a prospective cohort study Ceftolozane-Tazobatam for febrile neutropenia

  Francesco Marchesi, Fabrizio Ensoli, Irene Terrenato, Elena Papa, Fulvia Pimpinelli, Grazia Prignano, Antonio Spadea, Ilaria Cavallo, Enea Gino Di Domenico, Luigi Toma, Andrea Mengarelli

  e2020065

  2020-09-07

  https://doi.org/10.4084/mjhid.2020.065

  7822

  PDF: 716

  HTML: 209

• CHIMERIC ANTIGEN RECEPTOR T CELLS FOR THE TREATMENT OF MULTIPLE MYELOMA CAR T Cells and Myeloma Treatment

  Ugo Testa, Elvira Pelosi, Dr. Germana Castelli

  e2024077

  2024-10-31

  https://doi.org/10.4084/MJHID.2024.077

  1701

  PDF: 830

  HTML: 142

• INCREASE IN CANDIDA PARAPSILOSIS CANDIDEMIA IN CANCER PATIENTS

  Mingyue Sun, Chunguang Chen, weiqiang xiao, yanmin Chang, cailin Liu, Qingxia Xu

  e2019012

  2019-01-01

  https://doi.org/10.4084/mjhid.2019.012

  1746

  PDF: 1068

  HTML: 245

• Editorial : INTRODUCING MEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASES

  Giuseppe Leone, Luigi Maria Larocca, Eligio Pizzigallo

  e2009001

  2009-06-22

  3312

  PDF: 582

  HTML: 651